Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.64 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.57 |
| ▸ | AURKA | O14965 | 11/20 | 0.55 |
| ▸ | PLK1 | P53350 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31079063 | 0.85 | NPC1 (0.63) | NPC1MAPTMAPK1RAB9AMEN1 | |
| SCHEMBL3300205 | 0.80 | AURKA (0.86) | NPC1MAPTMAPK1RAB9AMEN1 | |
| SCHEMBL4621303 | 0.78 | NPC1 (0.87) | NPC1MAPTMAPK1RAB9AMEN1 | |
| Oxalic Acid SCHEMBL4608690 | 0.77 | PLK1 (0.56) | NPC1MAPTMAPK1RAB9AMEN1 | |
| SCHEMBL3301709 | 0.77 | MEN1 (0.69) | NPC1MAPTMAPK1RAB9AMEN1 | |
| SCHEMBL3300933 | 0.74 | AURKA (0.80) | NPC1RAB9AMAPK8AURKAAURKB | |
| SCHEMBL14009478 | 0.74 | MEN1 (0.61) | NPC1MAPTMAPK1RAB9AMEN1 | |
| SCHEMBL13844955 | 0.74 | MAPK1 (0.79) | NPC1MAPTMAPK1RAB9AMEN1 | |
| SCHEMBL29226498 | 0.74 | RAB9A (0.47) | NPC1MAPTMAPK1RAB9AMEN1 | |
| SCHEMBL2769055 | 0.74 | RAB9A (0.47) | NPC1MAPTMAPK1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4651872-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF USE TO TREAT HYPOPARATHYROIDISM AND OSTEOPOROSIS | Septerna, Inc. (US) | 2025-11-26 | — | — | EP | disclosed |
| WO-2024155601-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF USE TO TREAT HYPOPARATHYROIDISM AND OSTEOPOROSIS | SEPTERNA, INC. (US) | 2024-07-25 | — | — | WO | disclosed |