Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 6/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 6/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL29963900 | 0.93 | PARP10 (0.40) | PARP10PARP11MAPK1MAPKAPK2GSK3B | |
| SCHEMBL29964651 | 0.93 | PARP10 (0.45) | PARP10PARP11MAPK1MAPKAPK2ALOX5AP | |
| Trifluoroacetic Acid SCHEMBL31079143 | 0.87 | PARP10 (0.42) | PARP10PARP11MAPK1MAPKAPK2GSK3B | |
| Trifluoroacetic Acid SCHEMBL29964620 | 0.87 | PARP10 (0.42) | PARP10PARP11MAPK1MAPKAPK2GSK3B | |
| SCHEMBL29964391 | 0.85 | PARP10 (0.45) | PARP10PARP11MAPK1MAPKAPK2GSK3B | |
| Trifluoroacetic Acid SCHEMBL29964949 | 0.84 | PARP10 (0.39) | PARP10PARP11MAPK1MAPKAPK2GSK3B | |
| Trifluoroacetic Acid SCHEMBL29963911 | 0.84 | CCNT1 (0.47) | PARP10PARP11MAPK1MAPKAPK2GSK3B | |
| SCHEMBL31079103 | 0.82 | PARP10 (0.55) | PARP10PARP11MAPK1MAPKAPK2GSK3B | |
| SCHEMBL29963990 | 0.82 | ALOX5AP (0.37) | PARP10PARP11P2RY14MAPK1MAPKAPK2 | |
| SCHEMBL29964354 | 0.79 | MAPK1 (0.47) | PARP10PARP11MAPK1MAPKAPK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2024-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | CMPK1, WNK1, AAK1 | PARP10 2072/4885PARP11 1176/4885P2RY14 1350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.