WNK1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL3997164	0.48	5/20
SCHEMBL428100	0.53	3/20
SCHEMBL8037981	0.43	3/20
SCHEMBL1542018	0.70	2/20
SCHEMBL7541568	0.63	2/20
SCHEMBL6164640	0.61	2/20
SCHEMBL6164732	0.61	2/20
SCHEMBL6166721	0.61	2/20
SCHEMBL8607686	0.61	2/20
SCHEMBL6138625	0.60	2/20
SCHEMBL6138632	0.60	2/20
SCHEMBL9395556	0.60	2/20
SCHEMBL2387562	0.59	2/20
SCHEMBL7185722	0.59	2/20
SCHEMBL6562168	0.59	2/20
SCHEMBL7479621	0.59	2/20
SCHEMBL1925077	0.57	2/20
SCHEMBL2030586	0.57	2/20
SCHEMBL9575766	0.57	2/20
SCHEMBL6043899	0.56	2/20

Clinical trials — most relevant to WNK1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Salt Loading and Thiazide Intervention Study	PHASE4	COMPLETED
Kallikrein-kinin (KKS) and Renin-angiotensin-aldosterone System (RAAS) in Primary Aldosteronism	PHASE4	COMPLETED
Hepato-renal Regulation of Water Conservation in Heart Failure Patients With SGLT-2 Inhibitor Treatment	PHASE4	COMPLETED
Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study	PHASE4	RECRUITING
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity	PHASE4	COMPLETED
The Role of Mineralocorticoid Receptors in Vascular Function	PHASE2/PHASE3	COMPLETED
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome	PHASE3	COMPLETED
Selective Treatment According to Molecular Subtype of Prostate Cancer	PHASE2	UNKNOWN
Everolimus for Children With Recurrent or Progressive Ependymoma	PHASE2	COMPLETED
A Broad Multi-histology Phase II Study of the Multi-Kinase Inhibitor R935788 (Fostamatinib Disodium) in Advanced Colorectal, Non-small Cell Lung, Head and Neck Hepatocellular and Renal Cell Carcinomas, and Pheochromocytoma and Thyroid Tumors (Multi-H...	PHASE2	COMPLETED
Effect of Gene Variants on Dopamine Receptor Natriuretic Responses	PHASE1	UNKNOWN
Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure	EARLY_PHASE1	COMPLETED
Effects of Different Forms of a Natural Heart Hormone on Blood Pressure and Fluid Balance in Healthy Volunteers	EARLY_PHASE1	COMPLETED
POTASSIUM-RICH SALT SUBSTITUTES IN KIDNEY TRANSPLANT RECIPIENTS	nan	NOT_YET_RECRUITING
Transauricular Vagus Nerve Stimulation for Chronic Whiplash Associated Disorders	nan	RECRUITING
Establishment of Aldosterone and Renin Reference Range	nan	UNKNOWN
Urinary Kallikrein and Hypertension: A Prospective Study	nan	COMPLETED
From Micro- to Macro-vessels : Water, Salt, Heart and Kidneys	nan	COMPLETED
SEMASEARCH, Retrospective/Prospective Cohort Nested at ATUc/AP2 WEGOVY®	nan	COMPLETED
Molecular Phenotype Changes and Personalized Treatment for CRPC	nan	UNKNOWN
Podocyts Integrity in Glomerular Diseases	nan	UNKNOWN
HYPGENE-Genetics Fitness Obesity & Risk of Hypertension	nan	COMPLETED
The TEMPO (Tracing the Effect of the MC4 Pathway in Obesity) Registry	nan	COMPLETED
Defining the Brain Phenotype of Children With Williams Syndrome	nan	RECRUITING
Study of Metabolic Modifications in Children With Noonan Syndrome	nan	COMPLETED
Effects of Habitual Water Intake on Thirst in Healthy Young Adults Explained by Osmoadaptive Metabolism, Brain and Kidney Function (Adapt-Thirst)	nan	NOT_YET_RECRUITING
Ischemic Preconditioning - Perspectives of Use Vivio/in Vitro Studies	nan	ENROLLING_BY_INVITATION
The Effects of Isotonic and Hypertonic Saline Infusion on Renal Biomarkers in Healthy Young Subjects	nan	COMPLETED
Evaluation of Human Melanocytes After the Use of PRP Versus Fractional CO2 Laser in Vitiligo	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a WNK1 binder may also engage these)

Protein	Name	Similarity
P83741	—	1.000	P83741 →
Q6R2V0	—	1.000	Q6R2V0 →
Q9JIH7	—	0.996	Q9JIH7 →
BMP2K	BMP-2-inducible protein kinase	0.991	landscape →
P0C1X8	—	0.991	P0C1X8 →
Q9Z191	—	0.990	Q9Z191 →
O95677	—	0.990	O95677 →
F1MH24	—	0.990	F1MH24 →
Q96L91	—	0.989	Q96L91 →
Q9Y2X9	—	0.989	Q9Y2X9 →
Q8CHI8	—	0.989	Q8CHI8 →
Q80TZ9	—	0.989	Q80TZ9 →
Q2KHR2	—	0.989	Q2KHR2 →
A0JN51	—	0.989	A0JN51 →
Q4VYR7	—	0.989	Q4VYR7 →
Q9ULH7	—	0.989	Q9ULH7 →
Q60775	—	0.989	Q60775 →
Q99PM1	—	0.989	Q99PM1 →
Q91Z96	—	0.988	Q91Z96 →
AAK1	AP2-associated protein kinase 1	0.988	landscape →
Q6DJL0	—	0.988	Q6DJL0 →
Q2EJA0	—	0.988	Q2EJA0 →
Q3UHJ0	—	0.988	Q3UHJ0 →
Q66J90	—	0.988	Q66J90 →
Q86TC9	—	0.988	Q86TC9 →
Q62901	—	0.988	Q62901 →
Q3UH66	—	0.988	Q3UH66 →
Q7TN99	—	0.988	Q7TN99 →
P06536	—	0.988	P06536 →
A2RUV4	—	0.988	A2RUV4 →