Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | PRKACG | P22612 | 1/20 | 0.38 |
| ▸ | PRKACB | P22694 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.38 |
| ▸ | PARP11 | Q9NR21 | 6/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31079324 | 0.95 | MAPK1 (0.50) | MAPK1PRKACAPRKACGPRKACBPARP10 | |
| SCHEMBL31079278 | 0.91 | MAPK1 (0.35) | MAPK1PRKACAPRKACGPRKACBMAPKAPK2 | |
| SCHEMBL29964579 | 0.89 | MAPKAPK2 (0.42) | MAPK1PARP10PARP11MAPKAPK2GABRG2 | |
| SCHEMBL29964565 | 0.89 | MAPK1 (0.40) | MAPK1PARP10PARP11GSK3BMAPKAPK2 | |
| SCHEMBL29964735 | 0.88 | MAPK1 (0.41) | MAPK1PARP10PARP11GSK3BMAPKAPK2 | |
| SCHEMBL31079116 | 0.87 | PARP10 (0.43) | MAPK1PARP10PARP11GSK3BMAPKAPK2 | |
| SCHEMBL29963798 | 0.86 | MAPK1 (0.49) | MAPK1PARP10PARP11GSK3BMAPKAPK2 | |
| SCHEMBL29964574 | 0.86 | MAPK1 (0.38) | MAPK1PARP10PARP11GSK3BMAPKAPK2 | |
| SCHEMBL31079204 | 0.86 | MAPK1 (0.41) | MAPK1GSK3BGABRG2GABRB3GABRA5 | |
| SCHEMBL27159858 | 0.86 | MAPK1 (0.46) | MAPK1PRKACAPRKACGPRKACBPARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2024-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | CMPK1, WNK1, AAK1 | MAPK1 141/4885PRKACA 149/4885PRKACG 223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.