Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.30 |
| ▸ | WDR5 | P61964 | 2/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
| ▸ | TNF | P01375 | 1/20 | 0.30 |
| ▸ | CDC7 | O00311 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31079248 | 1.00 | MAPK1 (0.35) | MAPK1GRM2BACE1MAPKAPK2TBK1 | |
| SCHEMBL31078967 | 1.00 | MAPK1 (0.35) | MAPK1GRM2BACE1MAPKAPK2TBK1 | |
| SCHEMBL31079073 | 0.96 | MAPK1 (0.36) | MAPK1MAPKAPK2TBK1KDM4EKMT2A | |
| SCHEMBL31079232 | 0.95 | MAPK1 (0.34) | MAPK1MAPKAPK2TBK1PARP1PARP2 | |
| SCHEMBL31079379 | 0.93 | MAPK1 (0.42) | MAPK1GRM2BACE1MAPKAPK2TBK1 | |
| SCHEMBL31079090 | 0.93 | MAPK1 (0.42) | MAPK1GRM2BACE1MAPKAPK2TBK1 | |
| SCHEMBL31079085 | 0.93 | MAPK1 (0.42) | MAPK1GRM2BACE1MAPKAPK2TBK1 | |
| SCHEMBL29163464 | 0.90 | MAPK1 (0.33) | MAPK1GRM2BACE1MAPKAPK2KDM4E | |
| SCHEMBL29163280 | 0.90 | MAPK1 (0.33) | MAPK1GRM2BACE1MAPKAPK2KDM4E | |
| SCHEMBL29163285 | 0.90 | MAPK1 (0.33) | MAPK1GRM2BACE1MAPKAPK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2024-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | CMPK1, WNK1, AAK1 | MAPK1 141/4885GRM2 4347/4885BACE1 4686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.