Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.34 |
| ▸ | CDK2 | P24941 | 5/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30676318 | 0.83 | ADORA2A (0.36) | ADORA2AADORA1HCAR3CCNA2CDK2 | |
| SCHEMBL10741783 | 0.76 | DPP4 (0.41) | ADORA2AADORA1NPC1RAB9AKDM4E | |
| SCHEMBL29393193 | 0.76 | DPP4 (0.41) | ADORA2AADORA1NPC1RAB9AKDM4E | |
| SCHEMBL2228004 | 0.75 | DGAT1 (0.32) | CCNA2CDK2CCNA1CDK5DYRK1A | |
| SCHEMBL22598707 | 0.75 | PSMB8 (0.41) | ADORA2AADORA1HCAR3HPGDMEN1 | |
| SCHEMBL30441919 | 0.75 | LRRK2 (0.44) | ADORA2AADORA1HCAR3HPGDMEN1 | |
| SCHEMBL3484896 | 0.73 | IRAK4 (0.47) | ADORA2AADORA1DYRK1APDE4APDE4B | |
| SCHEMBL20665062 | 0.71 | IRAK4 (0.37) | — | |
| SCHEMBL15723772 | 0.71 | SMN1; SMN2 (0.41) | ADORA2AADORA1HCAR3CCNA2CDK2 | |
| SCHEMBL30442033 | 0.71 | IRAK4 (0.55) | CDK2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113227089-B | Substituted 6-azabenzimidazole compounds as HPK1 inhibitors | 吉利德科学公司 | 2024-07-05 | — | — | CN | disclosed |