SCHEMBL31080077

SCHEMBL31080077

Cc1cc(OCc2ccc(F)cc2F)c(Cl)c(=O)n1-c1cc(CNS(C)(=O)=O)ccc1F

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 18/20 0.59
MAPKAPK2 P49137 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5861958 1.00 MAPK14 (0.59) MAPK14MAPKAPK2
SCHEMBL4379628 0.86 MAPK14 (0.65) MAPK14MAPKAPK2
SCHEMBL31079582 0.86 MAPK14 (0.65) MAPK14MAPKAPK2
SCHEMBL5862997 0.86 MAPK14 (0.62) MAPK14MAPKAPK2
SCHEMBL4381608 0.85 MAPK14 (0.65) MAPK14MAPKAPK2
SCHEMBL5862529 0.85 MAPK14 (0.66) MAPK14MAPKAPK2
SCHEMBL29594257 0.85 MAPK14 (0.66) MAPK14MAPKAPK2
SCHEMBL4384583 0.84 MAPK14 (0.75) MAPK14MAPKAPK2
SCHEMBL30335800 0.84 MAPK14 (0.75) MAPK14MAPKAPK2
Hydrochloric Acid SCHEMBL4374293 0.84 MAPK14 (0.64) MAPK14MAPKAPK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114748622-B P38 kinase inhibitors reduce DUX4 and downstream gene expression and treat FSHD 弗尔康医疗公司 2024-09-24 CN disclosed
CN-114732910-B P38 kinase inhibitors reduce DUX4 and downstream gene expression and treat FSHD 弗尔康医疗公司 2024-08-23 CN disclosed