Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3103464 | 0.95 | GAA (0.66) | GAAMAPK1ALDH1A1HSD17B10MAPT | |
| SCHEMBL1976156 | 0.87 | GAA (0.69) | GAAMAPK1ALDH1A1HSD17B10MAPT | |
| SCHEMBL3107873 | 0.87 | GAA (0.69) | GAAMAPK1ALDH1A1HSD17B10MAPT | |
| SCHEMBL15277871 | 0.87 | GAA (0.69) | GAAMAPK1ALDH1A1HSD17B10MAPT | |
| SCHEMBL1976632 | 0.87 | GAA (0.69) | GAAMAPK1ALDH1A1HSD17B10MAPT | |
| SCHEMBL3113240 | 0.87 | GAA (0.69) | GAAMAPK1ALDH1A1HSD17B10MAPT | |
| SCHEMBL3113249 | 0.85 | GAA (0.71) | GAAMAPK1ALDH1A1HSD17B10MAPT | |
| SCHEMBL810348 | 0.81 | GAA (0.77) | GAAMAPK1ALDH1A1HSD17B10MAPT | |
| SCHEMBL3095198 | 0.79 | GAA (0.55) | GAAMAPK1ALDH1A1HSD17B10MAPT | |
| SCHEMBL1973680 | 0.78 | GAA (1.00) | GAAMAPK1ALDH1A1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324227-B2 | Thieno[2,3-D]-pyrimidin-4(3H)-one compounds with antifungal properties and process thereof | FDC LIMITED (US) | 2012-12-04 | — | — | US | disclosed |
| EP-2257555-B1 | THIENO[2,3-D]-PYRIMIDINE-4(3H)-ONE COMPOUNDS WITH ANTIFUNGAL PROPERTIES AND PROCESS THEREOF | NAT CHEMICAL LAB (IN) | 2012-07-04 | — | — | EP | disclosed |
| EP-2257555-A1 | THIENO[2,3-D]-PYRIMIDINE-4(3H)-ONE COMPOUNDS WITH ANTIFUNGAL PROPERTIES AND PROCESS THEREOF | National Chemical Laboratory (IN) | 2010-12-08 | — | — | EP | disclosed |
| US-20100273815-A1 | THIENO[2,3-D]-PYRIMIDIN-4(3H)-ONE COMPOUNDS WITH ANTIFUNGAL PROPERTIES AND PROCESS THEREOF | FDC LIMITED | 2010-10-28 | — | — | US | disclosed |
| WO-2009109983-A1 | THIENO[2,3-D]-PYRIMIDINE-4(3H)-ONE COMPOUNDS WITH ANTIFUNGAL PROPERTIES AND PROCESS THEREOF | NATIONAL CHEMICAL LABORATORY (IN) | 2009-09-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273815-A1 | THIENO[2,3-D]-PYRIMIDIN-4(3H)-ONE COMPOUNDS WITH ANTIFUNGAL PROPERTIES AND PROCESS THEREOF | ERG28, DPM1, CYP51A1 | GAA 228/4885MAPK1 1319/4885ALDH1A1 834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.