SCHEMBL31083124

SCHEMBL31083124

Clc1cccc(Br)c1C=C(Br)Br

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.41
ALDH1A1 P00352 2/20 0.41
MEN1 O00255 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
SLC22A1 O15245 1/20 0.36
HTR1A P08908 1/20 0.36
ADRA2A P08913 1/20 0.36
CHRM1 P11229 1/20 0.36
ADRA2B P18089 1/20 0.36
ADRA2C P18825 1/20 0.36
MAOA P21397 1/20 0.36
DRD1 P21728 1/20 0.36
TBXA2R P21731 1/20 0.36
SLC6A2 P23975 1/20 0.36
ADRA1D P25100 1/20 0.36
HTR2A P28223 1/20 0.36
HTR2C P28335 1/20 0.36
SLC6A4 P31645 1/20 0.36
ADRA1A P35348 1/20 0.36
OPRM1 P35372 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL955093 0.87 ALDH1A1 (0.48) KMT2AALDH1A1MEN1TDP1SLC22A1
SCHEMBL956733 0.78 ALDH1A1 (0.40) KMT2AALDH1A1MEN1TDP1SLC22A1
SCHEMBL16632534 0.77 MAOB (0.43) KMT2AALDH1A1MEN1TDP1MTOR
SCHEMBL611923 0.74 ALDH1A1 (0.70) KMT2AALDH1A1MEN1TDP1SLC22A1
SCHEMBL31257925 0.74 ALDH1A1 (0.70) KMT2AALDH1A1MEN1TDP1SLC22A1
SCHEMBL23043311 0.74 ALDH1A1 (0.44) KMT2AALDH1A1MEN1TDP1SLC22A1
SCHEMBL31256460 0.74 ALDH1A1 (0.44) KMT2AALDH1A1MEN1TDP1SLC22A1
SCHEMBL1725870 0.72 ALDH1A1 (0.67) KMT2AALDH1A1MEN1TDP1SLC22A1
SCHEMBL31083097 0.72 ALDH1A1 (0.43) KMT2AALDH1A1MEN1TDP1SLC22A1
SCHEMBL31732969 0.71 KMT2A (0.41) KMT2AALDH1A1MEN1TDP1SLC22A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024182788-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. (US) 2024-09-06 WO disclosed