Lithium Ion

Lithium Ion

SCHEMBL3108414

Cc1ccc2cc(C[O-])ccc2c1.[Li+]

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GSK3AGSK3BIMPA1

The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 5/20 0.56
CYP1A2 P05177 5/20 0.56
TDP1 Q9NUW8 1/20 0.48
ALDH1A1 P00352 3/20 0.35
NCK1 P16333 1/20 0.35
BACE1 P56817 1/20 0.35
KDM4E B2RXH2 1/20 0.35
LMNA P02545 1/20 0.35
GAA P10253 1/20 0.35
HPGD P15428 1/20 0.35
HSD17B10 Q99714 1/20 0.35
IDO1 P14902 1/20 0.34
CA12 O43570 3/20 0.34
CA9 Q16790 3/20 0.34
F2R P25116 1/20 0.33
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
HTR2B P41595 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Potassium Ion SCHEMBL3120221 0.96 CYP2A6 (0.56) CYP2A6CYP1A2TDP1ALDH1A1NCK1
SCHEMBL3107236 0.96 CYP2A6 (0.56) CYP2A6CYP1A2TDP1ALDH1A1NCK1
SCHEMBL29786773 0.77 CYP1A2 (0.64) CYP2A6CYP1A2TDP1ALDH1A1NCK1
Lithium Ion SCHEMBL3115424 0.77 CYP1A2 (0.58) CYP2A6CYP1A2CA9HTR2AHTR2C
SCHEMBL599076 0.77 CYP1A2 (0.64) CYP2A6CYP1A2TDP1ALDH1A1NCK1
Lithium Ion SCHEMBL937156 0.76 IDO1 (0.50) CYP2A6CYP1A2TDP1ALDH1A1LMNA
SCHEMBL6232099 0.76 CYP2A6 (0.59) CYP2A6CYP1A2TDP1ALDH1A1NCK1
SCHEMBL3565973 0.76 CYP1A2 (0.59) CYP2A6CYP1A2TDP1ALDH1A1NCK1
SCHEMBL14527632 0.76 CYP1A2 (0.59) CYP2A6CYP1A2TDP1ALDH1A1NCK1
SCHEMBL3083839 0.76 CYP2A6 (0.59) CYP2A6CYP1A2TDP1ALDH1A1NCK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8344171-B2 Process for making dihydrocarbyl hydrocarbonphosphonates ALBEMARLE CORPORATION (US) 2013-01-01 US disclosed
US-20100179342-A1 PROCESS FOR MAKING DIHYDROCARBYL HYDROCARBONPHOSPHONATES ALBEMARLE CORPORATION (US) 2010-07-15 US disclosed
EP-2164853-A1 PROCESS FOR MAKING DIHYDROCARBYL HYDROCARBONPHOSPHONATES Albermarle Corporation (US) 2010-03-24 EP disclosed
WO-2008154268-A1 PROCESS FOR MAKING DIHYDROCARBYL HYDROCARBONPHOSPHONATES ALBEMARLE CORPORATION (US) 2008-12-18 WO disclosed