Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 11/20 | 0.45 |
| ▸ | UTS2R | Q9UKP6 | 9/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.45 |
| ▸ | AKT1 | P31749 | 6/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.39 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2957289 | 0.90 | OPRK1 (0.57) | OPRK1UTS2RCYP3A4CYP2D6AKT1 | |
| SCHEMBL3117129 | 0.88 | OPRK1 (0.56) | OPRK1UTS2RCYP3A4CYP2D6OPRM1 | |
| SCHEMBL3103255 | 0.86 | OPRK1 (0.60) | OPRK1UTS2RCYP3A4CYP2D6AKT1 | |
| SCHEMBL3114714 | 0.85 | OPRK1 (0.48) | OPRK1UTS2RCYP3A4CYP2D6AKT1 | |
| SCHEMBL3109022 | 0.84 | OPRK1 (0.51) | OPRK1UTS2RCYP3A4CYP2D6 | |
| SCHEMBL3105170 | 0.84 | OPRK1 (0.50) | OPRK1UTS2RCYP3A4CYP2D6AKT1 | |
| SCHEMBL2953730 | 0.84 | OPRK1 (0.56) | OPRK1UTS2RCYP3A4CYP2D6RPS6KB1 | |
| SCHEMBL2953425 | 0.83 | OPRK1 (0.64) | OPRK1UTS2RCYP3A4CYP2D6OPRM1 | |
| SCHEMBL2957541 | 0.83 | OPRK1 (0.64) | OPRK1UTS2RCYP3A4CYP2D6OPRM1 | |
| SCHEMBL2957820 | 0.82 | UTS2R (0.52) | OPRK1UTS2RCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256130-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | GOODMAN KRISTA B | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256130-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | UTS2R, AVPR2, VIPR2 | OPRK1 207/4885UTS2R 1/4885CYP3A4 4049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.