Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 10/20 | 0.60 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25221943 | 1.00 | ACVR1 (0.60) | ACVR1PAK4WDR5JAK2JAK3 | |
| SCHEMBL25196046 | 0.90 | ACVR1 (0.50) | ACVR1PAK4WDR5JAK2JAK3 | |
| SCHEMBL25195068 | 0.80 | ACVR1 (0.65) | ACVR1PAK4WDR5JAK2CDK5 | |
| SCHEMBL25201204 | 0.77 | ACVR1 (0.47) | ACVR1PAK4WDR5CCNA2CDK2 | |
| SCHEMBL20589604 | 0.76 | ACVR1 (1.00) | ACVR1 | |
| SCHEMBL20589159 | 0.76 | ACVR1 (1.00) | ACVR1 | |
| SCHEMBL31095382 | 0.76 | ACVR1 (1.00) | ACVR1 | |
| SCHEMBL25212165 | 0.75 | ACVR1 (0.62) | ACVR1PAK4WDR5CYP2D6CYP2C9 | |
| SCHEMBL20589975 | 0.75 | ACVR1 (0.61) | ACVR1PAK4WDR5JAK2JAK3 | |
| SCHEMBL31095453 | 0.75 | ACVR1 (0.61) | ACVR1PAK4WDR5JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119060060-A | Imidazole-containing ALK2 kinase inhibitors | 拜奥克里斯特制药公司 | 2024-12-03 | — | — | CN | disclosed |
| CN-110913855-B | Imidazole-containing ALK2 kinase inhibitors | 拜奥克里斯特制药公司 | 2024-09-03 | — | — | CN | disclosed |