Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SELL | P14151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31346078 | 0.91 | TTR (0.40) | TTRMAPTKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL32665527 | 0.81 | KDM4E (0.37) | TTRMAPTKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL3892350 | 0.79 | MAPT (0.43) | TTRMAPTKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL18894055 | 0.79 | CA9 (0.36) | TTRMAPTKDM4EHSD17B10CYP3A4 | |
| SCHEMBL13090168 | 0.79 | KDM4E (0.43) | MAPTKDM4EHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL19308335 | 0.77 | KDM4E (0.55) | TTRMAPTKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL7871735 | 0.77 | MAPT (0.42) | TTRMAPTKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL12583448 | 0.77 | TTR (0.33) | TTRDAO | |
| SCHEMBL10304843 | 0.77 | TTR (0.33) | TTRDAO | |
| SCHEMBL7724120 | 0.77 | KDM4E (0.55) | MAPTKDM4EHSD17B10ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024255412-A1 | SPIRO HETEROCYCLIC COMPOUND AND USE THEREOF | 广州必贝特医药股份有限公司 | 2024-12-19 | — | — | WO | disclosed |
| CN-118510780-A | Spiro heterocyclic compounds and uses thereof | 广州必贝特医药股份有限公司 | 2024-08-16 | — | — | CN | disclosed |