Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 4/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | CTSE | P14091 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27229526 | 0.90 | LMNA (0.49) | LMNASMN1; SMN2MAPTALDH1A1TP53 | |
| SCHEMBL27090313 | 0.85 | LMNA (0.53) | LMNASMN1; SMN2MAPTALDH1A1TP53 | |
| SCHEMBL27229519 | 0.82 | MAPT (0.50) | LMNASMN1; SMN2MAPTALDH1A1TP53 | |
| SCHEMBL28525675 | 0.81 | LMNA (0.55) | LMNASMN1; SMN2MAPTALDH1A1TP53 | |
| SCHEMBL27090299 | 0.80 | LMNA (0.54) | LMNASMN1; SMN2MAPTALDH1A1TP53 | |
| SCHEMBL31099102 | 0.80 | LMNA (0.41) | LMNASMN1; SMN2MAPTALDH1A1TP53 | |
| SCHEMBL31207279 | 0.80 | LMNA (0.41) | LMNASMN1; SMN2MAPTALDH1A1TP53 | |
| SCHEMBL31207265 | 0.79 | MEN1 (0.43) | LMNASMN1; SMN2MAPTALDH1A1TP53 | |
| SCHEMBL31099109 | 0.78 | LMNA (0.40) | LMNASMN1; SMN2MAPTALDH1A1TP53 | |
| SCHEMBL31207240 | 0.78 | LMNA (0.40) | LMNASMN1; SMN2MAPTALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024255412-A1 | SPIRO HETEROCYCLIC COMPOUND AND USE THEREOF | 广州必贝特医药股份有限公司 | 2024-12-19 | — | — | WO | disclosed |
| CN-118510780-A | Spiro heterocyclic compounds and uses thereof | 广州必贝特医药股份有限公司 | 2024-08-16 | — | — | CN | disclosed |