Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 13/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.36 |
| ▸ | HCK | P08631 | 5/20 | 0.36 |
| ▸ | SRC | P12931 | 4/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | FYN | P06241 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 4/20 | 0.34 |
| ▸ | ABL1 | P00519 | 3/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | STK25 | O00506 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | GAK | O14976 | 1/20 | 0.33 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31106079 | 0.90 | LCK (0.38) | LCKMAPK14HCKSRCMAPK13 | |
| SCHEMBL31105882 | 0.90 | LCK (0.38) | LCKMAPK14HCKSRCMAPK13 | |
| SCHEMBL31105877 | 0.89 | LCK (0.37) | LCKMAPK14HCKSRCMAPK13 | |
| SCHEMBL31106170 | 0.86 | KRAS (0.36) | LCKMAPK14HCKSRCMAPK13 | |
| SCHEMBL31106116 | 0.82 | LCK (0.38) | LCKMAPK14HCKSRCMAPK13 | |
| SCHEMBL31105912 | 0.81 | MAPK14 (0.50) | LCKMAPK14HCKSRCMAPK13 | |
| SCHEMBL31106084 | 0.81 | LCK (0.36) | LCKMAPK14HCKSRCMAPK13 | |
| SCHEMBL31105889 | 0.80 | HCK (0.44) | LCKMAPK14HCKSRCMAPK13 | |
| SCHEMBL31105893 | 0.79 | LCK (0.41) | LCKMAPK14HCKSRCMAPK13 | |
| SCHEMBL31705188 | 0.79 | LCK (0.52) | LCKMAPK14HCKSRCMAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024184520-A1 | BIARYLAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-09-12 | — | — | WO | disclosed |