Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.31 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | BPTF | Q12830 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24558296 | 1.00 | KDM4E (0.37) | KDM4EALDH1A1GAAHTTSMN1; SMN2 | |
| SCHEMBL24558219 | 0.85 | HTT (0.33) | HTTSMN1; SMN2P2RX7MEN1KMT2A | |
| SCHEMBL24558226 | 0.74 | KDM4E (0.34) | KDM4EALDH1A1GAASMN1; SMN2MEN1 | |
| SCHEMBL25464887 | 0.74 | PDE2A (0.33) | HTR2C | |
| SCHEMBL31107239 | 0.73 | TSHR (0.36) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL24558302 | 0.73 | TSHR (0.36) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL31444314 | 0.69 | KDM4E (0.40) | KDM4EALDH1A1GAASMN1; SMN2CYP1A2 | |
| SCHEMBL29851161 | 0.67 | PDE1C (0.34) | KDM4EALDH1A1GAATP53P2RX7 | |
| SCHEMBL31521427 | 0.66 | CYP1A2 (0.48) | KDM4EALDH1A1GAAHTTSMN1; SMN2 | |
| SCHEMBL31743371 | 0.66 | SCN9A (0.42) | KDM4EALDH1A1GAACYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113508118-B | Fused tricyclic compounds useful as anticancer agents | 阿斯利康(瑞典)有限公司 | 2024-07-19 | — | — | CN | disclosed |