Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.74 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.59 |
| ▸ | KIT | P10721 | 1/20 | 0.59 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.57 |
| ▸ | CDK8 | P49336 | 4/20 | 0.56 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.56 |
| ▸ | AXL | P30530 | 2/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.55 |
| ▸ | PLK4 | O00444 | 2/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.55 |
| ▸ | INSR | P06213 | 2/20 | 0.55 |
| ▸ | CDK1 | P06493 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL858100 | 1.00 | BRD4 (0.74) | BRD4MAP3K11PDGFRBPDGFRADYRK1A | |
| SCHEMBL30173311 | 0.87 | BRD4 (0.65) | BRD4MAP3K11PDGFRBPDGFRADYRK1A | |
| SCHEMBL720887 | 0.85 | BRD4 (1.00) | BRD4MAP3K11KITRIPK1CDK8 | |
| SCHEMBL182642 | 0.85 | PIK3CA (0.69) | BRD4MAP3K11PDGFRBPDGFRADYRK1A | |
| SCHEMBL14620778 | 0.83 | BRD4 (0.63) | BRD4MAP3K11PDGFRBPDGFRADYRK1A | |
| SCHEMBL12127570 | 0.82 | BRD4 (0.65) | BRD4PDGFRBPDGFRADYRK1ARIPK1 | |
| SCHEMBL414175 | 0.81 | BRD4 (0.63) | BRD4MAP3K11PDGFRBPDGFRADYRK1A | |
| SCHEMBL4831501 | 0.80 | CDK8 (0.81) | BRD4PDGFRBPDGFRADYRK1ARIPK1 | |
| SCHEMBL415161 | 0.80 | BRD4 (0.67) | BRD4PDGFRBPDGFRADYRK1ARIPK1 | |
| SCHEMBL28504554 | 0.79 | BRD4 (0.58) | BRD4MAP3K11DYRK1ARIPK1CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240294522-A1 | 3-SUBSTITUTED 1H-PYRROLO[2,3-B]PYRIDINE AS GRK5 MODULATORS | LEAD DISCOVERY CENTER GMBH (DE) | 2024-09-05 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240294522-A1 | 3-SUBSTITUTED 1H-PYRROLO[2,3-B]PYRIDINE AS GRK5 MODULATORS | GRK5, GRK3, GRK4 | BRD4 347/4885MAP3K11 89/4885PDGFRB 590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.