Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 11/20 | 0.81 |
| ▸ | AXL | P30530 | 2/20 | 0.81 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.79 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.79 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.79 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.79 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.76 |
| ▸ | PLK4 | O00444 | 2/20 | 0.65 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.65 |
| ▸ | INSR | P06213 | 2/20 | 0.65 |
| ▸ | CDK1 | P06493 | 2/20 | 0.65 |
| ▸ | ROS1 | P08922 | 2/20 | 0.65 |
| ▸ | FER | P16591 | 2/20 | 0.65 |
| ▸ | CDK2 | P24941 | 2/20 | 0.65 |
| ▸ | MARK3 | P27448 | 2/20 | 0.65 |
| ▸ | FLT4 | P35916 | 2/20 | 0.65 |
| ▸ | KDR | P35968 | 2/20 | 0.65 |
| ▸ | SYK | P43405 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL410704 | 0.90 | CDK8 (1.00) | CDK8AXLPIK3CAPIK3CDPIK3CB | |
| SCHEMBL416750 | 0.89 | PIK3CA (1.00) | CDK8AXLPIK3CAPIK3CDPIK3CB | |
| SCHEMBL415099 | 0.89 | PIK3CA (0.70) | CDK8AXLPIK3CAPIK3CDPIK3CB | |
| SCHEMBL12127266 | 0.87 | RIPK1 (0.71) | CDK8AXLPIK3CAPIK3CDPIK3CB | |
| SCHEMBL410298 | 0.87 | RIPK1 (0.71) | CDK8AXLPIK3CAPIK3CDPIK3CB | |
| SCHEMBL22978455 | 0.87 | RIPK1 (1.00) | CDK8AXLPIK3CAPIK3CDPIK3CB | |
| SCHEMBL13854148 | 0.87 | CDK8 (0.65) | CDK8AXLPIK3CAPIK3CDPIK3CB | |
| SCHEMBL413503 | 0.87 | RIPK1 (0.71) | CDK8AXLPIK3CAPIK3CDPIK3CB | |
| SCHEMBL13854134 | 0.87 | CDK8 (0.65) | CDK8AXLPIK3CAPIK3CDPIK3CB | |
| SCHEMBL16746926 | 0.87 | RIPK1 (0.71) | CDK8AXLPIK3CAPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7446199-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-04 | — | — | US | disclosed |
| US-20050137201-A1 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137201-A1 | Compositions useful as inhibitors of protein kinases | MAP3K20, PACSIN2, MAP3K6 | CDK8 273/4885AXL 1103/4885PIK3CA 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.