SCHEMBL31119002

SCHEMBL31119002

COc1ccc(Cl)c(-c2ccnc(Cl)n2)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 2/20 0.55
HSP90AB1 P08238 2/20 0.55
KDM1A O60341 1/20 0.47
CCR1 P32246 1/20 0.44
CCR5 P51681 1/20 0.44
CCR8 P51685 1/20 0.44
PIK3CA P42336 3/20 0.43
PIK3CB P42338 3/20 0.43
PIK3CG P48736 3/20 0.43
DYRK1A Q13627 3/20 0.42
CLK1 P49759 2/20 0.42
CLK4 Q9HAZ1 2/20 0.42
CLK2 P49760 1/20 0.42
DYRK1B Q9Y463 1/20 0.42
GSK3B P49841 1/20 0.42
MAP3K14 Q99558 1/20 0.42
CYP1A1 P04798 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2E1 P05181 1/20 0.41
CYP3A4 P08684 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25339277 1.00 HSP90AA1 (0.55) HSP90AA1HSP90AB1KDM1ACCR1CCR5
SCHEMBL30450157 0.83 CYP1A1 (0.52) CCR1CCR5CCR8PIK3CAPIK3CB
SCHEMBL444455 0.83 CYP1A1 (0.52) CCR1CCR5CCR8PIK3CAPIK3CB
SCHEMBL25281127 0.78 IDO1 (0.46) PIK3CAPIK3CBPIK3CGDYRK1AGSK3B
SCHEMBL13934821 0.78 NPC1 (0.55) PIK3CAPIK3CBPIK3CGCYP1A1CYP1A2
SCHEMBL212750 0.77 NPC1 (0.61) PIK3CAPIK3CBPIK3CGDYRK1ACLK1
SCHEMBL30436606 0.76 MAP3K14 (0.73) DYRK1ACLK1CLK4GSK3BMAP3K14
SCHEMBL28696932 0.76 MAP3K14 (0.73) DYRK1ACLK1CLK4GSK3BMAP3K14
SCHEMBL28244309 0.76 DYRK1A (0.73) DYRK1ACLK1DYRK1BGSK3BMAP3K14
SCHEMBL16245868 0.76 CYP1A1 (0.70) CCR1CCR5CCR8PIK3CAPIK3CB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118891251-A Aryl hydrocarbon receptor agonists and uses thereof 奈可萨斯医药有限公司 2024-11-01 CN disclosed