Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.68 |
| ▸ | KDR | P35968 | 4/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.68 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.58 |
| ▸ | TUBB | P07437 | 2/20 | 0.58 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.58 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.58 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.58 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.58 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.58 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.58 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.58 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.58 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.58 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.58 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.58 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.58 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.58 |
| ▸ | CSF1R | P07333 | 7/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3122320 | 0.90 | EGFR (0.64) | EGFRKDRPDGFRBTUBB4ATUBB | |
| SCHEMBL3108888 | 0.86 | EGFR (0.76) | EGFRKDRPDGFRBTUBB4ATUBB | |
| SCHEMBL3110411 | 0.84 | EGFR (0.72) | EGFRKDRPDGFRBTUBB4ATUBB | |
| SCHEMBL3114872 | 0.84 | EGFR (0.72) | EGFRKDRPDGFRBTUBB4ATUBB | |
| SCHEMBL3115106 | 0.83 | KDR (0.70) | EGFRKDRPDGFRBTUBB4ATUBB | |
| SCHEMBL3115956 | 0.83 | EGFR (0.70) | EGFRKDRPDGFRBTUBB4ATUBB | |
| SCHEMBL2257339 | 0.81 | EGFR (1.00) | EGFRKDRPDGFRBTUBB4ATUBB | |
| SCHEMBL30960994 | 0.80 | EGFR (0.74) | EGFRKDRPDGFRBTUBB4ATUBB | |
| SCHEMBL3119177 | 0.80 | EGFR (0.74) | EGFRKDRPDGFRBTUBB4ATUBB | |
| Hydrochloric Acid SCHEMBL1685084 | 0.80 | EGFR (0.97) | EGFRKDRPDGFRBTUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100069383-A1 | COMPOUNDS AND THERAPEUTICAL USE THEREOF | Myriad Pharmaceuticals, Incorporated (US) | 2010-03-18 | — | — | US | claimed |
| US-20070249601-A1 | COMPOUNDS AND THERAPEUTICAL USE THEREOF | MYRIAD GENETICS, INCORPORATED (US) | 2007-10-25 | — | — | US | claimed |
| US-20070244114-A1 | COMPOUNDS AND THERAPEUTICAL USE THEREOF | MYRIAD GENETICS, INCORPORATED (US) | 2007-10-18 | — | — | US | claimed |
| US-20070244113-A1 | COMPOUNDS AND THERAPEUTICAL USE THEREOF | MYRIAD GENETICS, INCORPORATED (US) | 2007-10-18 | — | — | US | claimed |
| US-20070208044-A1 | COMPOUNDS AND THERAPEUTICAL USE THEREOF | MYRIAD GENETICS, INCORPORATED (US) | 2007-09-06 | — | — | US | claimed |
| JP-2007524637-A | — | — | 2007-08-30 | — | — | JP | claimed |
| EP-1660092-A2 | 4-ARYLAMINO-QUINAZOLINES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS | Myriad Genetics, Inc. (US) | 2006-05-31 | — | — | EP | claimed |
| US-20050137213-A1 | Compounds and therapeutical use thereof | MYRIAD GENETICS, INCORPORATED (US) | 2005-06-23 | — | — | US | claimed |
| WO-2005003100-A2 | 4-ARYLAMINO-QUINAZOLINES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS | MYRIAD GENETICS, INC. (US) | 2005-01-13 | — | — | WO | claimed |
| US-20170050937-A1 | COMPOUNDS AND THERAPEUTICAL USE THEREOF | MYRIAD GENETICS, INC. | 2017-02-23 | — | — | US | disclosed |
| US-20170050937-A1 | COMPOUNDS AND THERAPEUTICAL USE THEREOF | MYRIAD GENETICS, INC. | 2017-02-23 | — | — | US | disclosed |
| US-20170050937-A1 | COMPOUNDS AND THERAPEUTICAL USE THEREOF | MYRIAD GENETICS, INC. | 2017-02-23 | — | — | US | disclosed |
| US-20130029942-A1 | COMPOUNDS AND THERAPEUTICAL USES THEREOF | MYREXIS, INC. (US) | 2013-01-31 | — | — | US | disclosed |
| US-20130029942-A1 | COMPOUNDS AND THERAPEUTICAL USES THEREOF | MYREXIS, INC. (US) | 2013-01-31 | — | — | US | disclosed |
| US-20070208044-A1 | COMPOUNDS AND THERAPEUTICAL USE THEREOF | MYRIAD GENETICS, INCORPORATED (US) | 2007-09-06 | — | — | US | disclosed |
| US-20070208044-A1 | COMPOUNDS AND THERAPEUTICAL USE THEREOF | MYRIAD GENETICS, INCORPORATED (US) | 2007-09-06 | — | — | US | disclosed |
| US-20070208044-A1 | COMPOUNDS AND THERAPEUTICAL USE THEREOF | MYRIAD GENETICS, INCORPORATED (US) | 2007-09-06 | — | — | US | disclosed |
| EP-1660092-A2 | 4-ARYLAMINO-QUINAZOLINES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS | Myriad Genetics, Inc. (US) | 2006-05-31 | — | — | EP | disclosed |
| US-20050137213-A1 | Compounds and therapeutical use thereof | MYRIAD GENETICS, INCORPORATED (US) | 2005-06-23 | — | — | US | disclosed |
| WO-2005003100-A2 | 4-ARYLAMINO-QUINAZOLINES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS | MYRIAD GENETICS, INC. (US) | 2005-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208044-A1 | COMPOUNDS AND THERAPEUTICAL USE THEREOF | BAD, CASP3, BAX | EGFR 2915/4885KDR 3716/4885PDGFRB 2620/4885 |
| US-20130029942-A1 | COMPOUNDS AND THERAPEUTICAL USES THEREOF | BAD, CASP3, BAX | EGFR 3147/4885KDR 3722/4885PDGFRB 2783/4885 |
| US-20100069383-A1 | COMPOUNDS AND THERAPEUTICAL USE THEREOF | BAD, CASP3, BAX | EGFR 2648/4885KDR 3809/4885PDGFRB 2627/4885 |
| US-20070244113-A1 | COMPOUNDS AND THERAPEUTICAL USE THEREOF | BAD, CASP3, BAX | EGFR 2915/4885KDR 3716/4885PDGFRB 2620/4885 |
| US-20170050937-A1 | COMPOUNDS AND THERAPEUTICAL USE THEREOF | BAD, CASP3, BAX | EGFR 2915/4885KDR 3716/4885PDGFRB 2620/4885 |
| US-20050137213-A1 | Compounds and therapeutical use thereof | BAD, CASP3, BAX | EGFR 2915/4885KDR 3716/4885PDGFRB 2620/4885 |
| US-20070244114-A1 | COMPOUNDS AND THERAPEUTICAL USE THEREOF | BAD, CASP3, BAX | EGFR 2915/4885KDR 3716/4885PDGFRB 2620/4885 |
| US-20070249601-A1 | COMPOUNDS AND THERAPEUTICAL USE THEREOF | BAD, CASP3, BAX | EGFR 2915/4885KDR 3716/4885PDGFRB 2620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.