Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 1/20 | 0.64 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.64 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30293080 | 0.83 | SMARCA2 (0.57) | SMARCA2SMARCA4SORT1PORCNMEN1 | |
| SCHEMBL16055308 | 0.83 | SMARCA2 (0.57) | SMARCA2SMARCA4SORT1PORCNMEN1 | |
| SCHEMBL15880685 | 0.83 | SMARCA2 (0.65) | SMARCA2SMARCA4SORT1PORCNMEN1 | |
| SCHEMBL12442177 | 0.82 | PORCN (0.70) | PORCN | |
| SCHEMBL17804195 | 0.82 | SMARCA2 (0.64) | SMARCA2SMARCA4JAK2JAK1TYK2 | |
| SCHEMBL7672757 | 0.81 | SMARCA2 (0.63) | SMARCA2SMARCA4SORT1JAK2JAK1 | |
| SCHEMBL15890225 | 0.81 | PORCN (0.68) | SMARCA2SMARCA4SORT1PORCNSMN1; SMN2 | |
| SCHEMBL25235088 | 0.80 | SMARCA2 (0.54) | SMARCA2SMARCA4SORT1MEN1KMT2A | |
| SCHEMBL15880595 | 0.80 | SMARCA2 (0.61) | SMARCA2SMARCA4SORT1MEN1KMT2A | |
| SCHEMBL22125195 | 0.78 | SMARCA2 (1.00) | SMARCA2SMARCA4SORT1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240309019-A1 | TRICYCLIC HETEROARYL-SUBSTITUTED QUINOLINE AND AZAQUINOLINE COMPOUNDS AS PAR4 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2024-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240309019-A1 | TRICYCLIC HETEROARYL-SUBSTITUTED QUINOLINE AND AZAQUINOLINE COMPOUNDS AS PAR4 INHIBITORS | F2RL3, PARP14, F2R | SMARCA2 3441/4885SMARCA4 2329/4885SORT1 3520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.