Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22749849 | 0.79 | MPO (0.47) | LRRK2HSD11B1ELOVL1 | |
| SCHEMBL22749607 | 0.79 | MPO (0.47) | LRRK2HSD11B1ELOVL1 | |
| SCHEMBL22749608 | 0.79 | MPO (0.47) | LRRK2HSD11B1ELOVL1 | |
| SCHEMBL27122667 | 0.78 | KDM5A (0.34) | KDM5AF2PLAUKLKB1ELANE | |
| SCHEMBL27123399 | 0.78 | KDM5A (0.34) | KDM5AF2PLAUKLKB1ELANE | |
| SCHEMBL31547073 | 0.77 | KDM5A (0.36) | KDM5AF2PLAUKLKB1ELANE | |
| SCHEMBL27123040 | 0.77 | KDM5A (0.34) | KDM5AF2PLAUKLKB1ELANE | |
| SCHEMBL16876331 | 0.76 | KDM5A (0.38) | KDM5AF2PLAUKLKB1ELANE | |
| SCHEMBL1404089 | 0.75 | — | — | |
| SCHEMBL21995636 | 0.73 | KDM5A (0.39) | KDM5AF2PLAUKLKB1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688778-A1 | 1H-PYRROLO[2,3-B]PYRIDIN-4-YL]-2-OXOPYRROLIDINE-3-CARBONITRILE DERIVATIVES AS TYROSINE KINASE 2 (TYK2) INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | Biogen MA Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024211696-A1 | 1H-PYRROLO[2,3-B]PYRIDIN-4-YL]-2-OXOPYRROLIDINE-3-CARBONITRILE DERIVATIVES AS TYROSINE KINASE 2 (TYK2) INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | BIOGEN MA INC. (US) | 2024-10-10 | — | — | WO | disclosed |