Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | PPIA | P62937 | 3/20 | 0.49 |
| ▸ | XDH | P47989 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GCK | P35557 | 2/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.45 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31132542 | 1.00 | MAP4K4 (0.52) | MAP4K4PPIAXDHMEN1KMT2A | |
| SCHEMBL488339 | 0.82 | MAP4K4 (0.74) | MAP4K4XDHMEN1KMT2ANR4A2 | |
| SCHEMBL8881727 | 0.80 | MEN1 (0.54) | MAP4K4XDHMEN1KMT2AGCK | |
| SCHEMBL14333332 | 0.79 | PPIA (0.48) | MAP4K4PPIAXDHMEN1KMT2A | |
| SCHEMBL31133124 | 0.79 | HPGD (0.55) | MAP4K4XDHMEN1KMT2ANR4A2 | |
| SCHEMBL31132733 | 0.79 | HPGD (0.55) | MAP4K4XDHMEN1KMT2ANR4A2 | |
| SCHEMBL22502280 | 0.77 | RXRA (0.56) | MAP4K4XDHMEN1KMT2APTGER1 | |
| SCHEMBL3517697 | 0.76 | MEN1 (0.46) | MAP4K4PPIAXDHMEN1KMT2A | |
| SCHEMBL30892460 | 0.75 | KMT2A (0.51) | MAP4K4XDHMEN1KMT2ANR4A2 | |
| SCHEMBL1600077 | 0.73 | MRGPRX4 (0.62) | MEN1KMT2ANR4A2NR4A1NR4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4704830-A2 | MRGPRX2 INHIBITORS AND METHODS OF USE THEREOF | Septerna, Inc. (US) | 2026-03-11 | — | — | EP | disclosed |
| WO-2024226914-A2 | MRGPRX2 ANTAGONISTS AND METHODS OF USE THEREOF | SEPTERNA, INC. (US) | 2024-10-31 | — | — | WO | disclosed |