Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 3/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3108456 | 0.85 | MEN1 (0.48) | KMT2ASMN1; SMN2MEN1MET | |
| SCHEMBL3117008 | 0.84 | KMT2A (0.46) | KMT2ATDP1ALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL3112755 | 0.78 | KMT2A (0.40) | KMT2ASMN1; SMN2MEN1MET | |
| SCHEMBL3119810 | 0.76 | MEN1 (0.50) | KMT2ASMN1; SMN2MEN1MET | |
| SCHEMBL3119589 | 0.76 | MEN1 (0.50) | KMT2ASMN1; SMN2MEN1MET | |
| SCHEMBL3122723 | 0.76 | MET (0.48) | KMT2AMEN1MET | |
| SCHEMBL3112440 | 0.76 | MEN1 (0.50) | KMT2ASMN1; SMN2MEN1MET | |
| SCHEMBL3108392 | 0.75 | MET (0.47) | KMT2AMEN1MET | |
| SCHEMBL3109927 | 0.75 | HDAC1 (0.45) | KMT2AMEN1MET | |
| SCHEMBL3103580 | 0.74 | MEN1 (0.48) | KMT2ASMN1; SMN2MEN1MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367668-B2 | Pyridazinone derivatives | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2013-02-05 | — | — | US | disclosed |
| US-20100179148-A1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179148-A1 | PYRIDAZINONE DERIVATIVES | MET, ERBB2, RET | KMT2A 1002/4885TDP1 2917/4885ALDH1A1 851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.