Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.55 |
| ▸ | NPC1 | O15118 | 10/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.55 |
| ▸ | RELA | Q04206 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31139987 | 0.99 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL31139986 | 0.85 | PLAU (0.53) | RAB9ANPC1SMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL31139926 | 0.83 | MAP4K1 (0.44) | RAB9ANPC1SMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL31139953 | 0.81 | MAP4K1 (0.50) | — | |
| SCHEMBL31139940 | 0.81 | TRPV1 (0.46) | — | |
| SCHEMBL31139980 | 0.80 | NPC1 (0.59) | RAB9ANPC1SMN1; SMN2KMT2ATP53 | |
| SCHEMBL31139983 | 0.79 | TLK2 (0.45) | — | |
| SCHEMBL31139930 | 0.79 | SYK (0.50) | RAB9AKMT2AMEN1MAPK14 | |
| SCHEMBL31139975 | 0.76 | GRM5 (0.63) | RAB9ANPC1KMT2AMEN1LMNA | |
| SCHEMBL31139927 | 0.76 | TRPV1 (0.56) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240343707-A1 | SUBSTITUTED PHENYL ETHYNYL PYRIMIDINES AS POTENT INHIBITORS OF ALPHAVIRUSES | SOUTHERN RESEARCH INSTITUTE | 2024-10-17 | — | — | US | disclosed |
| WO-2024215771-A1 | SUBSTITUTED PHENYL ETHYNYL PYRIMIDINES AS POTENT INHIBITORS OF ALPHAVIRUSES | SOUTHERN RESEARCH INSTITUTE (US) | 2024-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240343707-A1 | SUBSTITUTED PHENYL ETHYNYL PYRIMIDINES AS POTENT INHIBITORS OF ALPHAVIRUSES | PRNP, PNP, ZC3HAV1 | RAB9A 967/4885NPC1 1306/4885SMN1; SMN2 2989/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.