Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 4/20 | 0.36 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 5/20 | 0.33 |
| ▸ | CTSB | P07858 | 5/20 | 0.33 |
| ▸ | CTSS | P25774 | 5/20 | 0.33 |
| ▸ | CTSK | P43235 | 5/20 | 0.33 |
| ▸ | GCGR | P47871 | 3/20 | 0.33 |
| ▸ | GIPR | P48546 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.31 |
| ▸ | NPY1R | P25929 | 1/20 | 0.31 |
| ▸ | F7 | P08709 | 1/20 | 0.31 |
| ▸ | F3 | P13726 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29796984 | 0.88 | SRC (0.38) | SRCXIAPGCGRGIPRGRM2 | |
| SCHEMBL26962177 | 0.88 | SRC (0.38) | SRCXIAPGCGRGIPRGRM2 | |
| SCHEMBL26961880 | 0.87 | KCNN4 (0.33) | CTSLCTSBCTSSCTSKGCGR | |
| SCHEMBL26962291 | 0.86 | SRC (0.37) | SRCXIAPGCGRGIPRGRM2 | |
| SCHEMBL29797032 | 0.85 | ABHD6 (0.33) | SRCXIAPGCGRGIPRGRM2 | |
| SCHEMBL26961815 | 0.85 | ABHD6 (0.33) | SRCXIAPGCGRGIPRGRM2 | |
| SCHEMBL26962547 | 0.85 | SRC (0.36) | SRCXIAPGCGRGIPRGRM2 | |
| SCHEMBL29797058 | 0.82 | SRC (0.39) | SRCXIAPNPY1RF7F3 | |
| SCHEMBL26961779 | 0.82 | SRC (0.39) | SRCXIAPNPY1RF7F3 | |
| SCHEMBL26961823 | 0.80 | XIAP (0.32) | SRCXIAPPDK2NPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240368150-A1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES FOR THE TREATMENT OF CANCER | HOFFMANN-LA ROCHE INC. (US) | 2024-11-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240368150-A1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES FOR THE TREATMENT OF CANCER | BICRA, BRD4, CNR1 | SRC 2202/4885XIAP 3779/4885CTSL 2128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.