Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Isopropyl Methylphosphonofluoridate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.30 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isopropyl Methylphosphonofluoridate SCHEMBL28755764 | 0.95 | CTSA (0.55) | CTSAACHEKDM4EALDH1A1POLB | |
| Isopropyl Methylphosphonofluoridate SCHEMBL292414 | 0.95 | CTSA (0.55) | CTSAACHEKDM4EALDH1A1POLB | |
| Isopropyl Methylphosphonofluoridate SCHEMBL13442719 | 0.92 | — | — | |
| Isopropyl Methylphosphonofluoridate SCHEMBL50256 | 0.92 | — | — | |
| Isopropyl Methylphosphonofluoridate SCHEMBL3917642 | 0.92 | CTSA (0.63) | CTSAACHEKDM4EALDH1A1POLB | |
| Isopropyl Methylphosphonofluoridate SCHEMBL19612794 | 0.89 | — | — | |
| Isopropyl Methylphosphonofluoridate SCHEMBL29918728 | 0.89 | — | — | |
| Isopropyl Methylphosphonofluoridate SCHEMBL32665920 | 0.89 | — | — | |
| Isopropyl Methylphosphonofluoridate SCHEMBL29555674 | 0.89 | — | — | |
| Isopropyl Methylphosphonofluoridate SCHEMBL29384739 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025036564-A1 | NUCLEIC ACID SEQUENCE, VECTOR, SCREENING METHOD AND METHOD OF PRODUCING RECOMBINANT ANTIBODIES | GOTTFRIED WILHELM LEIBNIZ UNIVERSITÄT HANNOVER (LUH) (DE) | 2025-02-20 | — | — | WO | disclosed |
| CN-118746861-A | Phosphorite-rich prospecting model and establishment method thereof | 贵州大学 | 2024-10-08 | — | — | CN | disclosed |