Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | HTR2C | P28335 | 4/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.54 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.52 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.52 |
| ▸ | KDM1A | O60341 | 3/20 | 0.47 |
| ▸ | PLAT | P00750 | 2/20 | 0.46 |
| ▸ | RAF1 | P04049 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15732539 | 0.85 | HTR2C (0.56) | MEN1POLBKMT2AHTR2CKDM1A | |
| SCHEMBL5203241 | 0.83 | KDM1A (0.46) | MEN1POLBKMT2AHTR2CMAPK13 | |
| Hydrochloric Acid SCHEMBL15732591 | 0.82 | HTR2C (0.46) | MEN1POLBKMT2AHTR2CMAPK13 | |
| SCHEMBL14608992 | 0.82 | KCNH2 (0.47) | MEN1POLBKMT2AKDM1AMAOB | |
| SCHEMBL5206565 | 0.82 | KCNH2 (0.47) | MEN1POLBKMT2AKDM1AMAOB | |
| SCHEMBL5205158 | 0.82 | KCNH2 (0.47) | MEN1POLBKMT2AKDM1AMAOB | |
| SCHEMBL311762 | 0.81 | PLAT (0.48) | MEN1POLBKMT2AHTR2CPLAT | |
| SCHEMBL5207210 | 0.81 | KDM1A (0.55) | MEN1POLBKMT2AMAPK13MAPK9 | |
| SCHEMBL312409 | 0.81 | SLC18A3 (0.50) | MEN1KMT2AHTR2C | |
| SCHEMBL312676 | 0.80 | KMO (0.44) | MEN1POLBKMT2AKDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2755965-B1 | NOVEL IMIDAZOLE AMINES AS MODULATORS OF KINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2017-07-26 | — | — | EP | disclosed |
| US-20160000785-A1 | Novel Imidazole Amines as Modulators of Kinase Activity | MERCK PATENT GMBH (DE) | 2016-01-07 | — | — | US | disclosed |
| US-9145392-B2 | Imidazole amines as modulators of kinase activity | MERCK PATENT GMBH (DE) | 2015-09-29 | — | — | US | disclosed |
| US-20140343029-A1 | Novel Imidazole Amines as Modulators of Kinase Activity | MERCK PATENT GMBH (DE) | 2014-11-20 | — | — | US | disclosed |
| CN-104080782-A | Novel imidazole amines as modulators of kinase activity | MERCK PATENT GMBH | 2014-10-01 | — | — | CN | disclosed |
| EP-2755965-A1 | NOVEL IMIDAZOLE AMINES AS MODULATORS OF KINASE ACTIVITY | Merck Patent GmbH (DE) | 2014-07-23 | — | — | EP | disclosed |
| EP-2148880-B1 | P70 S6 KINASE INHIBITORS | LILLY CO ELI (US) | 2014-05-28 | — | — | EP | disclosed |
| CN-101679439-B | P70S 6 kinase inhibitors | LILLY CO ELI | 2013-09-11 | — | — | CN | disclosed |
| WO-2013040059-A1 | NOVEL IMIDAZOLE AMINES AS MODULATORS OF KINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2013-03-21 | — | — | WO | disclosed |
| US-20120071490-A1 | P70 S6 KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2012-03-22 | — | — | US | disclosed |
| US-8093383-B2 | P70 S6 kinase inhibitors | ELI LILLY AND COMPANY (US) | 2012-01-10 | — | — | US | disclosed |
| CN-101679439-A | P70S 6 kinase inhibitors | LILLY CO ELI | 2010-03-24 | — | — | CN | disclosed |
| EP-2148880-A1 | P70 S6 KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2010-02-03 | — | — | EP | disclosed |
| US-20090163714-A1 | P70 S6 KINASE INHIBITORS | ELI LILLY AND COMPANY | 2009-06-25 | — | — | US | disclosed |
| WO-2008140947-A1 | P70 S6 KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2008-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160000785-A1 | Novel Imidazole Amines as Modulators of Kinase Activity | MAP3K11, MAP3K20, MAP3K19 | MEN1 1683/4885POLB 892/4885KMT2A 384/4885 |
| US-20090163714-A1 | P70 S6 KINASE INHIBITORS | RPS6KA6, RPS6KA1, RPS6KA2 | MEN1 3248/4885POLB 3457/4885KMT2A 3302/4885 |
| US-20140343029-A1 | Novel Imidazole Amines as Modulators of Kinase Activity | MAP3K11, MAP3K20, MAP3K19 | MEN1 1683/4885POLB 892/4885KMT2A 384/4885 |
| US-20120071490-A1 | P70 S6 KINASE INHIBITORS | RPS6KA6, RPS6KA1, RPS6KA2 | MEN1 3248/4885POLB 3457/4885KMT2A 3302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.