Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.58 |
| ▸ | CCND1 | P24385 | 14/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 13/20 | 0.58 |
| ▸ | CDK6 | Q00534 | 9/20 | 0.58 |
| ▸ | CDK4 | P11802 | 9/20 | 0.58 |
| ▸ | CCND3 | P30281 | 6/20 | 0.58 |
| ▸ | CCND2 | P30279 | 5/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.42 |
| ▸ | CDK9 | P50750 | 3/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19857375 | 1.00 | CDK2 (0.58) | CDK2CCND1CCNE1CDK6CDK4 | |
| SCHEMBL574660 | 0.87 | CCND1 (0.56) | CDK2CCND1CCNE1CDK6CDK4 | |
| SCHEMBL29990953 | 0.87 | CCND1 (0.56) | CDK2CCND1CCNE1CDK6CDK4 | |
| SCHEMBL5263603 | 0.86 | CCND1 (0.57) | CDK2CCND1CCNE1CDK6CDK4 | |
| SCHEMBL4828470 | 0.86 | CCND1 (0.57) | CDK2CCND1CCNE1CDK6CDK4 | |
| SCHEMBL31637530 | 0.84 | CCND1 (0.49) | CDK2CCND1CCNE1CDK6CDK4 | |
| SCHEMBL4828611 | 0.84 | CCND1 (0.49) | CDK2CCND1CCNE1CDK6CDK4 | |
| SCHEMBL24669667 | 0.82 | CDK2 (0.53) | CDK2CCND1CCNE1CDK6CDK4 | |
| SCHEMBL19863588 | 0.81 | CCNE1 (0.65) | CDK2CCND1CCNE1CDK6CDK4 | |
| SCHEMBL29798894 | 0.81 | CCNE1 (0.65) | CDK2CCND1CCNE1CDK6CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114394966-B | Pyridopyrimidinone CDK2/4/6 inhibitors | 辉瑞公司 | 2024-10-11 | — | — | CN | disclosed |