Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR174 | Q9BXC1 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 9/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | ACACA | Q13085 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LIPE | Q05469 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31155418 | 0.91 | GPR174 (0.44) | GPR174KCNH2MAPTALDH1A1LMNA | |
| SCHEMBL31155445 | 0.90 | MAPT (0.40) | GPR174KCNH2MAPTALDH1A1LMNA | |
| SCHEMBL25339805 | 0.89 | MAPT (0.43) | GPR174KCNH2MAPTALDH1A1LMNA | |
| SCHEMBL25340304 | 0.86 | KCNH2 (0.43) | GPR174KCNH2MAPTALDH1A1LMNA | |
| SCHEMBL310050 | 0.85 | MAPT (0.48) | MAPTALDH1A1LMNALIPEMET | |
| SCHEMBL31155444 | 0.84 | KCNH2 (0.42) | GPR174KCNH2MAPTALDH1A1LMNA | |
| SCHEMBL31155570 | 0.84 | RET (0.40) | GPR174MET | |
| SCHEMBL29094581 | 0.81 | MAPT (0.50) | GPR174KCNH2MAPTALDH1A1LMNA | |
| SCHEMBL25339252 | 0.81 | GPR174 (0.45) | GPR174MAPTALDH1A1LMNAACACB | |
| SCHEMBL25339886 | 0.81 | GPR174 (0.47) | GPR174MAPTALDH1A1LMNAACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024217481-A1 | EGFR DEGRADING AGENT, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | 上海齐鲁制药研究中心有限公司 | 2024-10-24 | — | — | WO | disclosed |