GPR174 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2017576	0.56	10/20
SCHEMBL275075	0.51	10/20
SCHEMBL274999	0.76	9/20
SCHEMBL274798	0.72	9/20
SCHEMBL274812	0.72	9/20
SCHEMBL275621	0.71	9/20
SCHEMBL275624	0.67	9/20
SCHEMBL521293	0.59	9/20
SCHEMBL521504	0.56	9/20
SCHEMBL521351	0.54	9/20
SCHEMBL3317301	0.79	8/20
SCHEMBL3315404	0.70	8/20
SCHEMBL3317049	0.77	7/20
SCHEMBL23963	0.75	7/20
Phosphatidyl Serine (SCHEMBL24649)	0.75	7/20
SCHEMBL25552	0.75	7/20
SCHEMBL237694	0.75	7/20
SCHEMBL314019	0.75	7/20
SCHEMBL416554	0.75	7/20
SCHEMBL2733430	0.75	7/20

Clinical trials — most relevant to GPR174 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
IMaging Della PLAcca Carotidea	PHASE3	COMPLETED
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
A Safety and Efficacy Study of Carbidopa-levodopa in Patients With Macular Degeneration	PHASE2	WITHDRAWN
Pharmacokinetics and Pharacodynamics of GW642444 in Paedetric Subjects	PHASE2	COMPLETED
A Study to Determine the Effect of CT3001 in Patients With Advanced Solid Tumors	PHASE1/PHASE2	RECRUITING
A118G SNP and OPRM1 Gene Opioid-Mediated Effects in Humans	PHASE2	COMPLETED
A Study With GW597599 And GR205171: Potential New Drugs For The Treatment Of Primary Insomnia	PHASE2	COMPLETED
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
An Investigation of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK2245035 in Healthy Volunteers and Allergic Rhinitics.	PHASE1	COMPLETED
The Role of Endocannabinoids in Insulin Production and Action	PHASE1	COMPLETED
Meclizine for Hepatocellular Carcinoma	PHASE1	COMPLETED
Assessment of [11C]ER176 to Image Translocator Protein in Brain and Whole Body of Healthy People	EARLY_PHASE1	COMPLETED
PET Brain and Whole Body Distribution Studies for Nociceptin/Orphanin FQ Peptide (NOP) Receptor Using [11C]NOP-1A	EARLY_PHASE1	COMPLETED
Oat Bran and Plasma Lipid and Fecal Bacteria in Coronary Artery Disease Patients	nan	COMPLETED
Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms	nan	COMPLETED
Neutrophil FFA2/GPR43 Receptor Expression in Patients With the Diagnosis of Sepsis	nan	WITHDRAWN
Genetic Influences of Albuterol Response In Children With Bronchiolitis	nan	COMPLETED
Longitudinal Analysis of Amylin Levels in Migraine Patients Undergoing an Anti- CGRP/CGRPr Treatment	nan	NOT_YET_RECRUITING
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation	nan	COMPLETED
Selective Activation of the Adrenomedullin Receptors in Migraine	nan	NOT_YET_RECRUITING
Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans.	nan	COMPLETED
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance	nan	UNKNOWN
Brain Receptors in Sympathetic Nervous System Regulation	nan	COMPLETED
Effect of Lower Doses of Colonic Nutrient Supplementation on Appetite Hormones and Food Intake in Obese Adults	nan	COMPLETED
Fat-induced Release of GLP-1 in Humans	nan	COMPLETED
Gastroparesis Registry 3	nan	COMPLETED
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism.	nan	NOT_YET_RECRUITING
Brain Imaging in Depression	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GPR174 binder may also engage these)

Protein	Name	Similarity
Q3U507	—	1.000	Q3U507 →
Q9XSD4	—	0.996	Q9XSD4 →
Q3U6B2	—	0.992	Q3U6B2 →
P2RY10	Putative P2Y purinoceptor 10	0.992	landscape →
CYSLTR2	Cysteinyl leukotriene receptor 2	0.992	landscape →
D4A7K7	—	0.992	D4A7K7 →
Q61038	—	0.991	Q61038 →
Q8C131	—	0.991	Q8C131 →
GPR183	G-protein coupled receptor 183	0.991	landscape →
B0UXR0	—	0.990	B0UXR0 →
Q95N02	—	0.990	Q95N02 →
Q80Z39	—	0.989	Q80Z39 →
P21556	—	0.989	P21556 →
Q9GK76	—	0.989	Q9GK76 →
GPR65	G-protein coupled receptor 65	0.989	landscape →
A5PLE7	—	0.989	A5PLE7 →
Q62035	—	0.988	Q62035 →
PTAFR	Platelet-activating factor receptor	0.988	landscape →
Q9TTY5	—	0.988	Q9TTY5 →
Q3UJF0	—	0.987	Q3UJF0 →
B5X337	—	0.987	B5X337 →
Q924T8	—	0.987	Q924T8 →
Q95N03	—	0.987	Q95N03 →
Q9EP66	—	0.987	Q9EP66 →
P46002	—	0.987	P46002 →
HCAR1	Hydroxycarboxylic acid receptor 1	0.986	landscape →
Q1RMI1	—	0.986	Q1RMI1 →
HCAR2	Hydroxycarboxylic acid receptor 2	0.986	landscape →
GPR55	G-protein coupled receptor 55	0.985	landscape →
Q2Y2P0	—	0.985	Q2Y2P0 →