Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | SLC18A3 | Q16572 | 6/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3128864 | 1.00 | SMN1; SMN2 (0.59) | SMN1; SMN2HPGDKMT2ASLC18A3SIGMAR1 | |
| SCHEMBL3120519 | 0.80 | SLC18A3 (0.56) | SMN1; SMN2HPGDKMT2ASLC18A3SIGMAR1 | |
| SCHEMBL3120525 | 0.80 | SLC18A3 (0.56) | SMN1; SMN2HPGDKMT2ASLC18A3SIGMAR1 | |
| SCHEMBL4072060 | 0.80 | SLC18A3 (0.64) | SMN1; SMN2HPGDKMT2ASLC18A3SIGMAR1 | |
| SCHEMBL3121558 | 0.80 | SLC18A3 (0.56) | SMN1; SMN2HPGDKMT2ASLC18A3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL4068642 | 0.79 | SLC18A3 (0.62) | SMN1; SMN2HPGDKMT2ASLC18A3SIGMAR1 | |
| SCHEMBL28189615 | 0.78 | SLC18A3 (0.53) | SMN1; SMN2HPGDKMT2ASLC18A3SIGMAR1 | |
| SCHEMBL28189614 | 0.78 | SLC18A3 (0.53) | SMN1; SMN2HPGDKMT2ASLC18A3SIGMAR1 | |
| SCHEMBL28268668 | 0.78 | SLC18A3 (0.53) | SMN1; SMN2HPGDKMT2ASLC18A3SIGMAR1 | |
| SCHEMBL21121132 | 0.78 | HPGD (0.65) | SMN1; SMN2HPGDKMT2ASLC18A3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |