Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 6/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3121558 | 1.00 | SLC18A3 (0.56) | SLC18A3GRIN2BCYP2D6CYP2C19AGTR2 | |
| SCHEMBL3120525 | 1.00 | SLC18A3 (0.56) | SLC18A3GRIN2BCYP2D6CYP2C19AGTR2 | |
| SCHEMBL4176060 | 0.90 | SLC18A3 (0.69) | SLC18A3GRIN2BCYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL3115994 | 0.80 | SMN1; SMN2 (0.59) | SLC18A3GRIN2BCYP2D6CYP2C19AGTR2 | |
| SCHEMBL3128864 | 0.80 | SMN1; SMN2 (0.59) | SLC18A3GRIN2BCYP2D6CYP2C19AGTR2 | |
| SCHEMBL28268668 | 0.78 | SLC18A3 (0.53) | SLC18A3GRIN2BCYP2D6CYP2C19AGTR2 | |
| SCHEMBL2931850 | 0.76 | RAB9A (0.54) | SLC18A3GRIN2BCYP2D6CYP2C19AGTR2 | |
| SCHEMBL2965273 | 0.76 | SLC18A3 (0.81) | SLC18A3GRIN2BCYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL27894548 | 0.76 | CYP2D6 (0.65) | SLC18A3CYP2D6CYP2C19AGTR2SMN1; SMN2 | |
| SCHEMBL299929 | 0.75 | CYP2D6 (0.68) | SLC18A3GRIN2BCYP2D6CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |