Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5895810 | 0.87 | ALDH1A1 (0.43) | EPHX1HRH3HPGDALDH1A1KDM4E | |
| SCHEMBL4930531 | 0.82 | PDE4B (0.39) | USP30EPHX1ALDH1A1KDM4EMAPT | |
| SCHEMBL29329053 | 0.81 | USP30 (0.42) | USP30HRH3HPGDALDH1A1CYP11B2 | |
| SCHEMBL31758157 | 0.79 | USP2 (0.39) | HPGDALDH1A1 | |
| SCHEMBL12543872 | 0.75 | USP30 (0.41) | USP30ALDH1A1CYP11B2KDM4EMAPT | |
| SCHEMBL3339309 | 0.75 | CYP1A2 (0.37) | ALDH1A1KDM4EMAPT | |
| SCHEMBL31566861 | 0.75 | USP30 (0.48) | USP30HRH3HPGDCYP11B2DDB1 | |
| SCHEMBL31171576 | 0.75 | USP30 (0.48) | USP30HRH3HPGDCYP11B2DDB1 | |
| SCHEMBL31567024 | 0.75 | USP30 (0.48) | USP30HRH3HPGDCYP11B2DDB1 | |
| SCHEMBL5895563 | 0.74 | KDM4E (0.43) | USP30EPHX1HRH3HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4680609-A1 | KRAS MODULATORS AND USES THEREOF | Quanta Therapeutics, Inc. (US) | 2026-01-21 | — | — | EP | disclosed |
| US-12421254-B2 | KRAS modulators and uses thereof | QUANTA THERAPEUTICS, INC. (US) | 2025-09-23 | — | — | US | disclosed |
| US-20250051365-A1 | KRAS MODULATORS AND USES THEREOF | QUANTA THERAPEUTICS, INC. | 2025-02-13 | — | — | US | disclosed |
| WO-2024192424-A1 | KRAS MODULATORS AND USES THEREOF | QUANTA THERAPEUTICS, INC. (US) | 2024-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12421254-B2 | KRAS modulators and uses thereof | KRAS, NRAS, HRAS | USP30 2549/4885EPHX1 3515/4885HRH3 2734/4885 |
| US-20250051365-A1 | KRAS MODULATORS AND USES THEREOF | KRAS, NRAS, HRAS | USP30 3189/4885EPHX1 2889/4885HRH3 2378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.