Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 12/20 | 1.00 |
| ▸ | FLT1 | P17948 | 11/20 | 0.78 |
| ▸ | KDR | P35968 | 5/20 | 0.78 |
| ▸ | FLT4 | P35916 | 4/20 | 0.78 |
| ▸ | PLK4 | O00444 | 3/20 | 0.78 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.78 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.78 |
| ▸ | LCK | P06239 | 3/20 | 0.78 |
| ▸ | LYN | P07948 | 3/20 | 0.78 |
| ▸ | RET | P07949 | 3/20 | 0.78 |
| ▸ | FLT3 | P36888 | 3/20 | 0.78 |
| ▸ | FRK | P42685 | 3/20 | 0.78 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.78 |
| ▸ | BLK | P51451 | 3/20 | 0.78 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.78 |
| ▸ | NEK2 | P51955 | 3/20 | 0.78 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.78 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.78 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.78 |
| ▸ | STK3 | Q13188 | 3/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3119077 | 0.88 | FLT1 (1.00) | RIPK1FLT1KDRFLT4PLK4 | |
| SCHEMBL3531509 | 0.84 | RIPK1 (0.72) | RIPK1FLT1KDRFLT4PLK4 | |
| SCHEMBL3117554 | 0.83 | FLT1 (1.00) | RIPK1FLT1KDRFLT4PLK4 | |
| SCHEMBL3122979 | 0.82 | KDR (0.78) | RIPK1FLT1KDRFLT4PLK4 | |
| SCHEMBL3124066 | 0.80 | AURKB (0.76) | RIPK1FLT1KDRFLT4PLK4 | |
| SCHEMBL3110624 | 0.80 | FLT1 (1.00) | RIPK1FLT1KDRFLT4PLK4 | |
| SCHEMBL4477648 | 0.80 | KDR (1.00) | RIPK1FLT1KDRFLT4PLK4 | |
| SCHEMBL14013999 | 0.79 | FLT1 (0.77) | RIPK1FLT1KDRFLT4PLK4 | |
| SCHEMBL3128213 | 0.78 | RIPK1 (0.67) | RIPK1FLT1KDRFLT4PLK4 | |
| Gw770249X SCHEMBL5652411 | 0.77 | TEK (1.00) | RIPK1FLT1KDRFLT4PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030225098-A1 | Kinase inhibitors | ABBOTT LABORATORIES | 2003-12-04 | — | — | US | claimed |
| US-20030199525-A1 | Kinase inhibitors | ABBOTT LABORATORIES | 2003-10-23 | — | — | US | claimed |
| US-7829570-B2 | Substituted 4-amino isoxazolo[5,4-d]pyrimidines as kinase inhibitors | ABBOTT LABORATORIES (US) | 2010-11-09 | — | — | US | disclosed |
| US-20100041676-A1 | Kinase inhibitors | ABBVIE INC. | 2010-02-18 | — | — | US | disclosed |
| US-20030225098-A1 | Kinase inhibitors | ABBOTT LABORATORIES | 2003-12-04 | — | — | US | disclosed |
| US-20030199525-A1 | Kinase inhibitors | ABBOTT LABORATORIES | 2003-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199525-A1 | Kinase inhibitors | MAP3K19, MAP3K9, MAP3K1 | RIPK1 653/4885FLT1 448/4885KDR 505/4885 |
| US-20030225098-A1 | Kinase inhibitors | MAP3K19, MAP3K9, MAP3K1 | RIPK1 642/4885FLT1 382/4885KDR 410/4885 |
| US-20100041676-A1 | Kinase inhibitors | MAP3K19, MAP3K20, MAP3K6 | RIPK1 520/4885FLT1 582/4885KDR 442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.