SCHEMBL31178024

SCHEMBL31178024

O=C1CCC(NC(=O)c2c(F)ccc3[nH]cnc23)C(=O)N1

nearest known ligand 0.58

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 20/20 0.58
DDB1 Q16531 4/20 0.49
BRD4 O60885 2/20 0.48
IKZF3 Q9UKT9 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23453693 1.00 CRBN (0.58) CRBNDDB1BRD4IKZF3
SCHEMBL23293635 0.80 CRBN (0.62) CRBNDDB1BRD4
SCHEMBL23453413 0.80 CRBN (0.55) CRBNDDB1BRD4IKZF3
SCHEMBL4780875 0.79 CRBN (0.68) CRBNDDB1IKZF3
SCHEMBL20811949 0.79 CRBN (0.83) CRBNDDB1BRD4IKZF3
SCHEMBL23453785 0.78 CRBN (0.56) CRBNDDB1BRD4IKZF3
SCHEMBL31178014 0.78 CRBN (0.56) CRBNDDB1BRD4IKZF3
SCHEMBL23453883 0.76 CRBN (0.50) CRBNDDB1BRD4IKZF3
SCHEMBL23453384 0.74 CRBN (0.61) CRBNDDB1BRD4IKZF3
SCHEMBL21751110 0.74 CRBN (1.00) CRBNDDB1BRD4IKZF3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240343706-A1 PIPERIDINE-2,6-DIONE DERIVATIVES WHICH BIND TO CEREBLON, AND METHODS OF USE THEREOF CAPTOR THERAPEUTICS S. A. (PL) 2024-10-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240343706-A1 PIPERIDINE-2,6-DIONE DERIVATIVES WHICH BIND TO CEREBLON, AND METHODS OF USE THEREOF CRBN, CDR2, DRD2 CRBN 1/4885DDB1 1161/4885BRD4 449/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.