Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.51 |
| ▸ | AKT1 | P31749 | 2/20 | 0.48 |
| ▸ | AKT2 | P31751 | 2/20 | 0.48 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | DDX6 | P26196 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | CSK | P41240 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31183798 | 0.90 | PIK3CA (0.48) | PIK3CAAKT1AKT2AKT3PIK3CB | |
| SCHEMBL31183667 | 0.90 | AKT1 (0.52) | PIK3CAAKT1AKT2AKT3PIK3CB | |
| SCHEMBL31183483 | 0.90 | AKT1 (0.52) | PIK3CAAKT1AKT2AKT3PIK3CB | |
| SCHEMBL31183358 | 0.89 | AKT1 (0.60) | PIK3CAAKT1AKT2AKT3 | |
| SCHEMBL31183615 | 0.89 | AKT1 (0.60) | PIK3CAAKT1AKT2AKT3 | |
| SCHEMBL31183861 | 0.87 | AKT1 (0.49) | PIK3CAAKT1AKT2AKT3PIK3CB | |
| SCHEMBL31183335 | 0.86 | PIK3CA (0.53) | PIK3CAAKT1AKT2AKT3PIK3CB | |
| SCHEMBL30808184 | 0.83 | PIK3CA (0.59) | PIK3CAAKT1AKT2AKT3PIK3CB | |
| SCHEMBL30808191 | 0.83 | PIK3CA (0.59) | PIK3CAAKT1AKT2AKT3PIK3CB | |
| SCHEMBL30808189 | 0.83 | PIK3CA (0.59) | PIK3CAAKT1AKT2AKT3PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240391882-A1 | Substituted Quinoxalines | Mirati Therapeutics, Inc. | 2024-11-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240391882-A1 | Substituted Quinoxalines | NQO2, NQO1, NDUFV3 | PIK3CA 2834/4885AKT1 3240/4885AKT2 3609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.