Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHKA | P35790 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2200195 | 0.89 | SLC18A3 (0.42) | SLC18A3ALDH1A1TSHRALOX15HSD17B10 | |
| SCHEMBL8121053 | 0.81 | SLC18A3 (0.60) | SLC18A3ALDH1A1TSHRALOX15HSD17B10 | |
| SCHEMBL26154043 | 0.81 | SLC18A3 (0.56) | SLC18A3ALDH1A1TSHRALOX15HSD17B10 | |
| SCHEMBL10052123 | 0.79 | SLC18A3 (0.58) | SLC18A3ALDH1A1TSHRALOX15HSD17B10 | |
| SCHEMBL1366969 | 0.78 | LMNA (0.42) | ALDH1A1TSHRHSD17B10PSMB5KDM4E | |
| SCHEMBL3970629 | 0.77 | SLC18A3 (0.43) | SLC18A3ALDH1A1TDP1MAPTTP53 | |
| SCHEMBL1663395 | 0.76 | SLC18A3 (0.55) | SLC18A3ALDH1A1TSHRALOX15HSD17B10 | |
| SCHEMBL10182294 | 0.76 | SLC18A3 (0.59) | SLC18A3ALDH1A1TSHRALOX15HSD17B10 | |
| Hydrochloric Acid SCHEMBL9255650 | 0.74 | SLC18A3 (0.53) | SLC18A3ALDH1A1TSHRALOX15HSD17B10 | |
| SCHEMBL14257946 | 0.74 | SLC18A3 (0.58) | SLC18A3ALDH1A1TSHRALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |