Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 13/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28525919 | 1.00 | NAMPT (0.37) | NAMPTEPHX2GPR119USP2SMN1; SMN2 | |
| SCHEMBL29715663 | 1.00 | NAMPT (0.37) | NAMPTEPHX2GPR119USP2SMN1; SMN2 | |
| SCHEMBL31184074 | 0.89 | PPM1D (0.32) | — | |
| SCHEMBL28448603 | 0.86 | EPHX2 (0.40) | NAMPTEPHX2GPR119USP2SMN1; SMN2 | |
| SCHEMBL31184329 | 0.83 | EPHX2 (0.43) | NAMPTEPHX2GPR119USP2SMN1; SMN2 | |
| SCHEMBL31387643 | 0.83 | EPHX2 (0.43) | NAMPTEPHX2GPR119USP2SMN1; SMN2 | |
| SCHEMBL28542108 | 0.82 | GPR119 (0.43) | NAMPTEPHX2GPR119USP2SMN1; SMN2 | |
| SCHEMBL31184180 | 0.82 | GPR119 (0.43) | NAMPTEPHX2GPR119USP2SMN1; SMN2 | |
| SCHEMBL16925331 | 0.81 | NAMPT (0.37) | NAMPTEPHX2GPR119USP2SMN1; SMN2 | |
| SCHEMBL21918484 | 0.81 | NAMPT (0.37) | NAMPTEPHX2GPR119USP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112625028-B | Compounds and compositions for inhibiting SHP2 activity | 诺华股份有限公司 | 2024-10-29 | — | — | CN | disclosed |