SCHEMBL31189232

SCHEMBL31189232

CC(C)(C(=O)O)c1cc(Br)ccc1C(=O)O

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.47
GLA P06280 1/20 0.47
PTGDR2 Q9Y5Y4 1/20 0.44
MYC P01106 1/20 0.44
NR4A1 P22736 1/20 0.44
SORT1 Q99523 10/20 0.40
RXFP1 Q9HBX9 2/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
GRIN1 Q05586 1/20 0.39
GRIN2A Q12879 1/20 0.39
GRIN2B Q13224 1/20 0.39
GRIN2C Q14957 1/20 0.39
GPR35 Q9HC97 1/20 0.39
GRIK1 P39086 1/20 0.39
ACLY P53396 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22745699 1.00 KDM4E (0.47) KDM4EGLAPTGDR2MYCNR4A1
SCHEMBL22716745 0.87 KDM4E (0.50) KDM4EGLAPTGDR2MYCNR4A1
SCHEMBL31189220 0.87 KDM4E (0.50) KDM4EGLAPTGDR2MYCNR4A1
SCHEMBL898260 0.85 PTGDR2 (0.54) KDM4EGLAPTGDR2MYCNR4A1
SCHEMBL25370828 0.83 PTGDR2 (0.45) KDM4EGLAPTGDR2MYCNR4A1
SCHEMBL16437892 0.80 PTGDR2 (0.43) KDM4EGLAPTGDR2KMT2A
SCHEMBL22716759 0.77 POLB (0.44) KDM4EGLAPTGDR2MYCNR4A1
SCHEMBL21872367 0.77 PTGDR2 (0.51) KDM4EGLAPTGDR2MEN1KMT2A
SCHEMBL19319661 0.77 KDM4E (0.43) KDM4EGLAPTGDR2MYCNR4A1
SCHEMBL257339 0.77 EPRS1 (0.51) KDM4EGLAMYCNR4A1GRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113874369-B 1,3, 4-Oxadiazole homophthalimide derivative compounds as histone deacetylase 6 inhibitors and pharmaceutical compositions containing the same 株式会社 钟根堂 2024-08-27 CN disclosed