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Sugi Predict / Targets / EPRS1

EPRS1

Bifunctional glutamate/proline--tRNA ligase · P07814 · EPRS1 on Sugi Atlas →

868 patent compounds predicted against EPRS1, 579 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL116080 SCHEMBL116080 1.00 6/20
SCHEMBL117482 SCHEMBL117482 1.00 6/20
SCHEMBL15919601 SCHEMBL15919601 0.67 6/20
SCHEMBL117434 SCHEMBL117434 1.00 5/20
SCHEMBL117228 SCHEMBL117228 0.65 5/20
SCHEMBL116062 SCHEMBL116062 0.64 5/20
SCHEMBL116064 SCHEMBL116064 0.55 5/20
SCHEMBL117388 SCHEMBL117388 1.00 4/20
SCHEMBL117405 SCHEMBL117405 0.71 4/20
SCHEMBL5792900 SCHEMBL5792900 0.71 4/20
SCHEMBL9580395 SCHEMBL9580395 0.67 4/20
SCHEMBL117224 SCHEMBL117224 0.67 4/20
SCHEMBL118475 SCHEMBL118475 0.65 4/20
SCHEMBL116081 SCHEMBL116081 0.64 4/20
SCHEMBL15905102 SCHEMBL15905102 0.64 4/20
SCHEMBL116058 SCHEMBL116058 0.62 4/20
SCHEMBL15919554 SCHEMBL15919554 0.60 4/20
SCHEMBL15919434 SCHEMBL15919434 0.59 4/20
SCHEMBL116073 SCHEMBL116073 0.52 4/20
SCHEMBL15919374 SCHEMBL15919374 0.48 4/20

Clinical trials — most relevant to EPRS1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
L-Arginine in Pre-Eclampsia PHASE3COMPLETED
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes PHASE2UNKNOWN
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy PHASE2ACTIVE_NOT_RECRUITING
EPI-743 in Cobalamin C Defect: Effects on Visual and Neurological Impairment PHASE2COMPLETED
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers PHASE2NOT_YET_RECRUITING
Digoxin for Congenital Erythrocytosis Due to Up-Regulated Hypoxia Sensing PHASE1WITHDRAWN
Tolerability of Enteral NAC in Infants PHASE1NOT_YET_RECRUITING
Mitoferrin-1 Expression in Erythropoietic Protoporphyria (Porphyria Rare Disease Clinical Research Consortium (RDCRC)) nanCOMPLETED
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer nanUNKNOWN
Natural History Study of FDXR Mutation-related Mitochondriopathy nanCOMPLETED
Review of French Cases of Glutathione Synthetase Deficiency nanUNKNOWN
Foci of Tumor Heterogeneity in Diffuse Low-Grade Gliomas nanCOMPLETED
French National Cohort of Patients With PRSS1 Mutations nanRECRUITING
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients nanCOMPLETED
Thiol/Disulphide Homeostasis in Unexplained Infertility nanCOMPLETED
Using Next-generation Sequencing in the Diagnosis of Epilepsy and/or Intellectual Disability in a Pediatric Cohorte nanCOMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
Genetic Analysis of Parkinson's Disease nanCOMPLETED
Genetic Variants and Regulation of Specialized Pro-resolving Mediator nanRECRUITING
Aswan Heart Centre - Egyptian Healthy Volunteers nanRECRUITING
Genetic Studies of Lysosomal Storage Disorders nanENROLLING_BY_INVITATION
New Genes Involved in Molecular Etiology of Rett Syndrome Through DNA Microarray Comparative Genomic Hybridization nanCOMPLETED
The Natural History of Patients With Mutations in SEPN1 (SELENON) or LAMA2 nanCOMPLETED
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione nanCOMPLETED
Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation nanUNKNOWN
Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt Lesions nanRECRUITING
Identification of a New Gene Involved in Hereditary Lipodystrophy nanCOMPLETED
Primary Hyperoxaluria Mutation Genotyping/Phenotyping nanCOMPLETED
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients. nanCOMPLETED
JAK-STAT Signalling Pathway in Familial Myeloproliferative Disorders nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a EPRS1 binder may also engage these)

ProteinNameSimilarity
Q7SIA2 — 1.000 Q7SIA2 →
Q8CGC7 — 1.000 Q8CGC7 →
P28668 — 0.999 P28668 →
Q54KR1 — 0.995 Q54KR1 →
Q5F408 — 0.994 Q5F408 →
Q9Y7Y8 — 0.994 Q9Y7Y8 →
P46655 — 0.994 P46655 →
P28350 — 0.993 P28350 →
CARS1 Cysteine--tRNA ligase, cytoplasmic 0.993 landscape →
Q54KB8 — 0.993 Q54KB8 →
Q291L4 — 0.992 Q291L4 →
Q5M7N8 — 0.992 Q5M7N8 →
O13775 — 0.992 O13775 →
O82462 — 0.991 O82462 →
G9N4A3 — 0.991 G9N4A3 →
Q5RA20 — 0.991 Q5RA20 →
P13188 — 0.990 P13188 →
Q9UUF2 — 0.990 Q9UUF2 →
P40122 — 0.990 P40122 →
Q09860 — 0.990 Q09860 →
Q4R550 — 0.990 Q4R550 →
Q43768 — 0.990 Q43768 →
P38025 — 0.990 P38025 →
Q9ZRI7 — 0.990 Q9ZRI7 →
Q9VTE6 — 0.990 Q9VTE6 →
Q55CU8 — 0.990 Q55CU8 →
RARS1 Arginine--tRNA ligase, cytoplasmic 0.990 landscape →
Q9MAB3 — 0.990 Q9MAB3 →
Q7ZWR2 — 0.990 Q7ZWR2 →
Q8RXN5 — 0.990 Q8RXN5 →