Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 11/20 | 0.56 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.31 |
| ▸ | PTGES | O14684 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.30 |
| ▸ | KDM5A | P29375 | 2/20 | 0.30 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.30 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.30 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | KDM4A | O75164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31196111 | 1.00 | RIPK1 (0.56) | RIPK1ATXN2FFAR4PTGESHCRTR2 | |
| SCHEMBL31196507 | 0.89 | RIPK1 (0.54) | RIPK1 | |
| SCHEMBL31196108 | 0.89 | RIPK1 (0.54) | RIPK1 | |
| SCHEMBL31196130 | 0.88 | RIPK1 (0.53) | RIPK1TBK1ACACB | |
| SCHEMBL31196316 | 0.88 | RIPK1 (0.53) | RIPK1TBK1ACACB | |
| SCHEMBL31196232 | 0.86 | RIPK1 (0.51) | RIPK1FFAR4 | |
| SCHEMBL31196165 | 0.86 | RIPK1 (0.51) | RIPK1FFAR4 | |
| SCHEMBL31196372 | 0.84 | RIPK1 (0.51) | RIPK1 | |
| SCHEMBL31196298 | 0.84 | RIPK1 (0.51) | RIPK1 | |
| SCHEMBL31196431 | 0.78 | RIPK1 (0.55) | RIPK1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709716-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2026-03-18 | — | — | EP | claimed |
| WO-2024233554-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2024-11-14 | — | — | WO | claimed |
| EP-4709716-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2026-03-18 | — | — | EP | disclosed |
| WO-2024233554-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2024-11-14 | — | — | WO | disclosed |