Sugi Predict

Sugi Predict / Compounds / SCHEMBL31196345

SCHEMBL31196345

SCHEMBL31196345

N#Cc1cc(F)cc([C@@H]2CCON2C(=O)[C@H]2CC[C@@H](O)CC2)c1

nearest known ligand 0.64

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ RIPK1 Q13546 12/20 0.64
▸ TRPM5 Q9NZQ8 1/20 0.32
▸ USP30 Q70CQ3 1/20 0.31
▸ MGLL Q99685 1/20 0.31
▸ PAX8 Q06710 1/20 0.31
▸ KCNK3 O14649 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30420762 0.90 RIPK1 (0.65) RIPK1TRPM5MGLLPAX8
SCHEMBL25190408 0.90 RIPK1 (0.65) RIPK1TRPM5MGLLPAX8
Hydrochloric Acid SCHEMBL31196383 0.89 RIPK1 (0.64) RIPK1TRPM5MGLL
Hydrochloric Acid SCHEMBL31196312 0.89 RIPK1 (0.64) RIPK1TRPM5MGLL
SCHEMBL31196299 0.88 RIPK1 (0.61) RIPK1TRPM5PAX8
SCHEMBL31200441 0.87 RIPK1 (0.60) RIPK1TRPM5
SCHEMBL31200286 0.87 RIPK1 (0.60) RIPK1TRPM5
SCHEMBL31200374 0.87 RIPK1 (0.60) RIPK1TRPM5
SCHEMBL31196449 0.87 RIPK1 (0.62) RIPK1TRPM5
Hydrochloric Acid SCHEMBL31196526 0.86 RIPK1 (0.61) RIPK1TRPM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709716-A1 ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF GENZYME CORPORATION (US) 2026-03-18 — — EP disclosed
WO-2024233554-A1 ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF GENZYME CORPORATION (US) 2024-11-14 — — WO disclosed