Chavicol

Chavicol

SCHEMBL3119862

C=CCc1ccc(O)cc1.O=C(O)O

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GSK3AGSK3BIMPA1

The experimentally established mechanism targets of Chavicol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 2/20 0.50
XDH P47989 1/20 0.50
CAMK2A Q9UQM7 1/20 0.50
ALDH1A1 P00352 3/20 0.48
KDM4E B2RXH2 1/20 0.48
MEN1 O00255 1/20 0.48
ALDH2 P05091 1/20 0.48
GAA P10253 1/20 0.48
MAPT P10636 1/20 0.48
GABRA1 P14867 1/20 0.48
AKR1B1 P15121 1/20 0.48
HPGD P15428 1/20 0.48
CNR1 P21554 1/20 0.48
CNR2 P34972 1/20 0.48
PPARG P37231 1/20 0.48
GABRB2 P47870 1/20 0.48
KMT2A Q03164 1/20 0.48
PPARD Q03181 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
CYP1A2 P05177 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chavicol SCHEMBL10525947 0.92 XDH (0.47) CA2XDHCAMK2AALDH1A1KDM4E
Chavicol SCHEMBL7209702 0.92 CYP1A2 (0.47) CA2XDHCAMK2AALDH1A1KDM4E
Chavicol SCHEMBL3871465 0.91 XDH (0.54) CA2XDHCAMK2AALDH1A1KDM4E
Chavicol SCHEMBL30870 0.91 XDH (0.58) CA2XDHALDH1A1KDM4EMEN1
Chavicol SCHEMBL11043594 0.89 XDH (0.56) CA2XDHALDH1A1KDM4EMEN1
Chavicol SCHEMBL7187339 0.89 XDH (0.56) CA2XDHALDH1A1KDM4EMEN1
Chavicol SCHEMBL7924978 0.89 XDH (0.56) CA2XDHALDH1A1KDM4EMEN1
Chavicol SCHEMBL10565597 0.89 XDH (0.56) CA2XDHALDH1A1KDM4EMEN1
Chavicol SCHEMBL10511637 0.89 XDH (0.56) CA2XDHALDH1A1KDM4EMEN1
Chavicol SCHEMBL5483528 0.89 XDH (0.56) CA2XDHALDH1A1KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010018177-A1 REACTION PRODUCTS OF OXAZOLIDINE DERIVATIVES AND OF BISOXAZOLIDINE DERIVATIVES, IN PARTICULAR WITH DERIVATIVES OF HYDROXYAROMATICS AND OF NITROGEN-CONTAINING COMPOUNDS, SUCH AS AMINOTRIAZINES BOREALIS AGROLINZ MELAMINE GMBH (AT) 2010-02-18 WO disclosed
EP-1456296-A1 ADDITIVE FOR INHIBITING PHOTOLYTIC DEGRADATION REACTIONS IN AMINOPLASTS AMI Agrolinz Melamine International GmbH (AT) 2004-09-15 EP disclosed
WO-2003054083-A1 ADDITIVE FOR INHIBITING PHOTOLYTIC DEGRADATION REACTIONS IN AMINOPLASTS AMI - AGROLINZ MELAMINE INTERNATIONAL GMBH (AT) 2003-07-03 WO disclosed