Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.62 |
| ▸ | DRD4 | P21917 | 2/20 | 0.62 |
| ▸ | DRD3 | P35462 | 1/20 | 0.62 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.40 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2301787 | 0.83 | DRD2 (0.60) | DRD2DRD4DRD3SRCNPC1 | |
| SCHEMBL9551505 | 0.77 | DRD2 (0.54) | DRD2DRD4DRD3SRCNPC1 | |
| SCHEMBL15441288 | 0.77 | DRD2 (0.54) | DRD2DRD4DRD3SRCNPC1 | |
| SCHEMBL15441290 | 0.77 | DRD2 (0.54) | DRD2DRD4DRD3SRCNPC1 | |
| SCHEMBL8482373 | 0.77 | DRD4 (1.00) | DRD2DRD4DRD3CYP19A1NAMPT | |
| Hydrochloric Acid SCHEMBL8131385 | 0.76 | DRD2 (0.53) | DRD2DRD4DRD3SRCNPC1 | |
| SCHEMBL19179891 | 0.75 | DRD2 (0.52) | DRD2DRD4DRD3SRCNPC1 | |
| SCHEMBL27812294 | 0.75 | DRD2 (0.58) | DRD2DRD4DRD3SRCNPC1 | |
| SCHEMBL19128795 | 0.73 | DRD2 (0.50) | DRD2DRD4DRD3SRCNPC1 | |
| SCHEMBL12369621 | 0.73 | DRD2 (0.50) | DRD2DRD4DRD3SRCNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |