Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.77 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.77 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.77 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | WNT3A | P56704 | 1/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31203377 | 0.89 | HDAC8 (0.75) | HDAC8HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL31203324 | 0.89 | HDAC8 (0.75) | HDAC8HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL31203347 | 0.87 | HDAC8 (1.00) | HDAC8HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL31203409 | 0.87 | HDAC8 (0.86) | HDAC8HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL31203404 | 0.82 | PTPN1 (0.53) | HDAC8HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL31203527 | 0.81 | HDAC8 (1.00) | HDAC8HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL31203354 | 0.77 | HDAC8 (0.60) | HDAC8HDAC6HDAC1HDAC3RAB9A | |
| SCHEMBL31203380 | 0.76 | HDAC8 (0.80) | HDAC8HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL17251987 | 0.75 | PDPK1 (0.68) | PAX8PDPK1DYRK1ANPC1RAB9A | |
| SCHEMBL6187983 | 0.73 | DYRK1A (0.70) | PDPK1DYRK1ANPC1RAB9APTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240360089-A1 | Metabolically Stable HDAC Inhibitors with Trifluoromethylpyruvamide as Metal-Binding Group | THE UNIVERSITY OF TOLEDO (US) | 2024-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240360089-A1 | Metabolically Stable HDAC Inhibitors with Trifluoromethylpyruvamide as Metal-Binding Group | HDAC1, HDAC3, HDAC2 | HDAC8 5/4885HDAC6 9/4885HDAC1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.