Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.53 |
| ▸ | PDE4A | P27815 | 9/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3131264 | 0.84 | MAPT (0.39) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL1157634 | 0.84 | PDE4D (0.60) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL3126358 | 0.83 | MEN1 (0.42) | PDE4B | |
| SCHEMBL3133700 | 0.83 | PDE4B (0.50) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL3132090 | 0.82 | GAA (0.39) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3131820 | 0.81 | GRM4 (0.44) | PDE4B | |
| SCHEMBL3132205 | 0.80 | PDE4B (0.48) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL1157408 | 0.78 | PDE4D (0.68) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL3120558 | 0.73 | PDE4B (0.49) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL28628502 | 0.73 | PDE4B (0.59) | PDE4BPDE4DPDE4APDE4CABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-02-04 | — | — | US | disclosed |
| WO-2010003084-A2 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE4B, PDE3B | PDE4B 2/4885PDE4D 9/4885PDE4A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.