Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3126358 | 0.89 | MEN1 (0.42) | MAPTMAPK1MEN1LMNAKMT2A | |
| SCHEMBL3132090 | 0.88 | GAA (0.39) | MAPTGAAKDM4EALDH1A1PDE4B | |
| SCHEMBL3131820 | 0.87 | GRM4 (0.44) | MAPTMAPK1MEN1LMNAKMT2A | |
| SCHEMBL3120568 | 0.84 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3200139 | 0.83 | KMT2A (0.52) | MAPTMEN1LMNAKMT2AGAA | |
| SCHEMBL3129616 | 0.81 | MAPT (0.43) | MAPTMAPK1MEN1LMNAKMT2A | |
| SCHEMBL3130711 | 0.78 | BRD4 (0.49) | MAPTMAPK1MEN1LMNAKMT2A | |
| SCHEMBL3201435 | 0.76 | MAPT (0.41) | MAPTMAPK1MEN1LMNAKMT2A | |
| SCHEMBL3129664 | 0.74 | MAPT (0.41) | MAPTMAPK1MEN1LMNAKMT2A | |
| SCHEMBL3132959 | 0.72 | MAPT (0.59) | MAPTMEN1LMNAKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003084-A2 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |