Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31205864 | 1.00 | HPGD (0.44) | HPGDGPR119RECQLEPHX1KDM4E | |
| SCHEMBL21776781 | 0.85 | RORC (0.43) | HPGDGPR119MAPTUSP2SMN1; SMN2 | |
| SCHEMBL26347371 | 0.84 | HPGD (0.46) | HPGDGPR119RECQLEPHX1KDM4E | |
| SCHEMBL9566442 | 0.82 | USP2 (0.44) | HPGDGPR119RECQLUSP2SMN1; SMN2 | |
| SCHEMBL9566436 | 0.82 | USP2 (0.44) | HPGDGPR119RECQLUSP2SMN1; SMN2 | |
| SCHEMBL9566391 | 0.82 | USP2 (0.44) | HPGDGPR119RECQLUSP2SMN1; SMN2 | |
| SCHEMBL9566458 | 0.82 | USP2 (0.44) | HPGDGPR119RECQLUSP2SMN1; SMN2 | |
| SCHEMBL9566382 | 0.82 | USP2 (0.44) | HPGDGPR119RECQLUSP2SMN1; SMN2 | |
| SCHEMBL9566412 | 0.82 | USP2 (0.44) | HPGDGPR119RECQLUSP2SMN1; SMN2 | |
| SCHEMBL31433665 | 0.82 | HPGD (0.44) | HPGDGPR119RECQLEPHX1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709723-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2026-03-18 | — | — | EP | disclosed |
| WO-2024233544-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2024-11-14 | — | — | WO | disclosed |