Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | SCD | O00767 | 4/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2304242 | 0.90 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3SCDEPHX2 | |
| SCHEMBL2297386 | 0.89 | SLC6A4 (0.56) | SLC6A4SLC6A2SLC6A3SCDEPHX2 | |
| SCHEMBL2300974 | 0.85 | SLC6A4 (0.54) | SLC6A4SLC6A2SLC6A3SCDEPHX2 | |
| SCHEMBL9281104 | 0.79 | SLC6A4 (0.65) | SLC6A4SLC6A2SLC6A3SCDEPHX2 | |
| SCHEMBL3129196 | 0.76 | SLC6A4 (0.41) | SLC6A4SLC6A2SLC6A3SCD | |
| SCHEMBL11959440 | 0.76 | SLC6A4 (0.61) | SLC6A4SLC6A2SLC6A3SCDEPHX2 | |
| SCHEMBL18573854 | 0.76 | SLC6A4 (0.61) | SLC6A4SLC6A2SLC6A3SCDEPHX2 | |
| SCHEMBL3515007 | 0.76 | RBP4 (0.46) | SCD | |
| SCHEMBL19139364 | 0.74 | SLC6A4 (0.59) | SLC6A4SLC6A2SLC6A3SCDEPHX2 | |
| SCHEMBL242185 | 0.74 | HRH1 (0.50) | SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |